Efficacy and safety of adalimumab 80 mg in the treatment of psoriasis: a bicentric retrospective study
| Autor: | A. Agusti-Mejias, Francesc Messeguer-Badia, Javier Sabater-Abad, Enrique Gimeno-Carpio, Laura Lorente-Fernández, María Matellanes-Palacios, Manuel Velasco-Pastor, Laia Bou-Boluda |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Dermatology Antibodies Monoclonal Humanized Severity of Illness Index 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Psoriasis medicine Adalimumab Humans Adverse effect Retrospective Studies business.industry Retrospective cohort study General Medicine medicine.disease Treatment Outcome Spain 030220 oncology & carcinogenesis Tumor necrosis factor alpha business medicine.drug |
| Zdroj: | Dermatologic therapyREFERENCES. 33(3) |
| ISSN: | 1529-8019 |
| Popis: | Adalimumab (ADA) is a recombinant human monoclonal antibody indicated for the treatment of psoriasis that specifically inhibits tumor necrosis factor. Until recently we only had the presentation of 40 mg of ADA, being the standard dose in adults an initial administration of 80 mg, followed by 40 mg every 2 weeks. Newly the presentation of 80 mg of ADA has been commercialized, allowing the administration of the standard dose or a higher dose, with fewer injections. In this study, we retrospectively studied 11 patients with psoriasis who have received treatment with the presentation of 80 mg of ADA in two dermatology departments of two hospitals in Spain since its commercialization until June 2019. At the end of the study, an improvement in the mean final Psoriasis Area Severity Index (PASI) of all patients was observed, without any patient presenting any adverse effects. This study shows the efficacy and safety of 80 mg of ADA in a sample of 11 patients with psoriasis. |
| Databáze: | OpenAIRE |
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