A Method for Repeated Evaluation of Benzene Uptake in Rats and Mice During a Six Hour Inhalation Period
| Autor: | William E. Rinehart, George M. Rusch, R A Kuna, M Eutermoser, J O'Grodnick |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Inhalation exposure Time Factors Chromatography Inhalation Chemistry Public Health Environmental and Occupational Health Benzene Mice Inbred Strains Rats Inbred Strains Benzene metabolism Rats Toxicology Kinetics Mice chemistry.chemical_compound Species Specificity Respiration Benzene toxicity Animals Benzene vapor Respiratory minute volume |
| Zdroj: | American Industrial Hygiene Association Journal. 47:37-40 |
| ISSN: | 0002-8894 |
| DOI: | 10.1080/15298668691389315 |
| Popis: | Benzene uptake measurements and respiratory minute volume (RMV) were assessed in rats and mice during a 6-hour inhalation exposure to 300 ppm (v/v) of benzene vapor. The values for benzene uptake and RMV were used to compare predictions of inhaled dose in both species. The theoretical prediction assumed an unchanging RMV. The next prediction allowed adjustments for changes in RMV during exposure. The final prediction addressed benzene uptake directly. The uptake characteristics of benzene in both species were different from the theoretical prediction, from the prediction adjusted for changing RMV and from each other. The greatest difference was seen in rats where the observed benzene dose was only 28% of the theoretical value. The experiment was not designed to elucidate the causes for the difference between the predictions, nor was the data sufficient to suggest whether the rat or the mouse was a suitable model of benzene uptake in humans. |
| Databáze: | OpenAIRE |
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