Dextran 40-Induced Coagulopathy Confused With von Willebrand Disease
| Autor: | Richard Brodman, Frank J. Veith, Michael Sarg, Theodore Spaet |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Hemophilia A Diagnosis Differential Bleeding time medicine Coagulopathy Von Willebrand disease Humans Postoperative Care Aspirin medicine.diagnostic_test business.industry Dextrans Blood Coagulation Disorders Middle Aged medicine.disease Surgery Bleeding diathesis von Willebrand Diseases Coagulation Cryoprecipitate Anesthesia business medicine.drug Partial thromboplastin time |
| Zdroj: | Archives of Surgery. 112:321 |
| ISSN: | 0004-0010 |
| DOI: | 10.1001/archsurg.1977.01370030093016 |
| Popis: | • In a patient who had undergone reconstructive surgery on the subclavian artery and was treated postoperatively with aspirin and dextran 40, a bleeding diathesis developed within 24 hours. This was at first thought to be von Willebrand disease, since the bleeding time was longer than ten minutes; the factor VIII level, 28%; and the activated partial thromboplastin time, 50 seconds (normal 30 to 38). The patient's defect responded to discontinuance of the low-molecular-weight, dextran and aspirin therapy and administration of a cryoprecipitate. Later studies of the coagulation mechanism up to two and one-half months were entirely normal. The postoperative defect therefore was assumed to have been the result of the administration of dextran and aspirin. It is possible that in a similar future case, discontinuance of dextran infusion and administration of a single bolus of 12 bags of cryoprecipitate may be adequate treatment. ( Arch Surg 112:321-322, 1977) |
| Databáze: | OpenAIRE |
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