Significantly greater expression of ER, PR, and ECAD in advanced-stage low-grade ovarian serous carcinoma as revealed by immunohistochemical analysis
| Autor: | Angela Thornton, Diane C. Bodurka, Hyun S. Shvartsman, Elvio G. Silva, David M. Gershenson, Michael T. Deavers, Kwong Kwok Wong, Rosemarie Schmandt, Karen H. Lu, Anais Malpica |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Stromal cell Serous carcinoma Estrogen receptor Pathology and Forensic Medicine Metastasis Ovarian tumor Cyclin D1 Progesterone receptor medicine Biomarkers Tumor Humans Neoplasm Staging Ovarian Neoplasms business.industry Obstetrics and Gynecology medicine.disease Cadherins Prognosis Immunohistochemistry Cystadenocarcinoma Serous DNA-Binding Proteins Ki-67 Antigen Matrix Metalloproteinase 9 Receptors Estrogen Female business Receptors Progesterone |
| Zdroj: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 26(4) |
| ISSN: | 0277-1691 |
| Popis: | A 2-tier system that classifies ovarian serous carcinoma (OSC) as low grade or high grade is gaining acceptance. Women with low-grade OSC generally have higher 5-year survival rates than do women with high-grade OSC. We examined the expression of various markers to further understand the molecular differences between low-grade and high-grade OSCs: the potential therapeutic targets or prognostic markers Her-2/neu, estrogen receptor, and progesterone receptor (PR); the metastasis-associated markers cyclin D1 (BCL1), E-cadherin, matrix metalloproteinase (MMP) 2, and MMP-9; and the cell proliferation-associated markers BCL1, Ki-67 antigen (Ki-67), and p53. For this immunohistochemical analysis, we used paraffin-embedded specimens from 47 patients with advanced-stage low-grade OSC and from 49 patients with advanced-stage high-grade OSC. Our results showed that low-grade tumors expressed significantly higher levels of estrogen receptor, PR, and E-cadherin than did high-grade tumors, suggesting the involvement of gonadal steroid hormones, especially in the pathogenesis of low-grade OSC; the PR positivity was also observed in the stromal component of these low-grade tumors. On the other hand, high-grade tumors trended toward increased expression of MMP-9, BCL1, p53, and Ki-67, and robust MMP-9 positivity was observed in the stromal component of these high-grade tumors. These differences may lead to the development of different therapeutic strategies for women with either the low-grade or the high-grade form of OSC. |
| Databáze: | OpenAIRE |
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