Common Infectious Agents and Monoclonal B-Cell Lymphocytosis: A Cross-Sectional Epidemiological Study among Healthy Adults

Autor: Casabonne, Delphine, Almeida, Julia, Nieto, Wendy G, Romero, Alfonso, Fernández Navarro, Paulino, Rodriguez Caballero, Arancha, Munoz Criado, Santiago, González Díaz, Marcos, Benavente, Yolanda, Sanjosé Llongueras, Silvia de, Orfao, Alberto, Primary Health Care Group of Salamanca for the Study of MBL
Přispěvatelé: Red Temática de Investigación Cooperativa en Cáncer (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Junta de Castilla y León, Asociación Española Contra el Cáncer, Generalitat de Catalunya
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Viral Diseases
B Cells
Lymphocytosis
Pulmonology
Cross-sectional study
Epidemiology
lcsh:Medicine
Infeccions respiratòries
Risk Factors
hemic and lymphatic diseases
Odds Ratio
Prevalence
lcsh:Science
Non-Hodgkin lymphoma
Aged
80 and over
B-Lymphocytes
Multidisciplinary
Hematology
Middle Aged
Infectious Diseases
Monoclonal
Monoclonal B-cell lymphocytosis
Medicine
Lymphomas
Female
medicine.symptom
Cancer Epidemiology
Research Article
Adult
medicine.medical_specialty
Cèl·lules B
Immune Cells
Immunology
chemical and pharmacologic phenomena
Infectious Disease Epidemiology
Internal medicine
medicine
Humans
Lymphocyte Count
Biology
Aged
B cells
business.industry
lcsh:R
Respiratory infections
Odds ratio
medicine.disease
bacterial infections and mycoses
Leukemia
Lymphocytic
Chronic
B-Cell
Pneumonia
Cross-Sectional Studies
Hematologic cancers and related disorders
Respiratory Infections
lcsh:Q
business
Zdroj: PLoS ONE
Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, Vol 7, Iss 12, p e52808 (2012)
ISSN: 1932-6203
Popis: This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- Primary Health Care Group of Salamanca for the Study of MBL: et al.
[Background]: Risk factors associated with monoclonal B-cell lymphocytosis (MBL), a potential precursor of chronic lymphocytic leukaemia (CLL), remain unknown. [Methods]: Using a cross-sectional study design, we investigated demographic, medical and behavioural risk factors associated with MBL. >Low-count> MBL (cases) were defined as individuals with very low median absolute count of clonal B-cells, identified from screening of healthy individuals and the remainder classified as controls. 452 individuals completed a questionnaire with their general practitioner, both blind to the MBL status of the subject. Odds ratios (OR) and 95% confidence interval (CI) for MBL were estimated by means of unconditional logistic regression adjusted for confounding factors. [Results]: MBL were detected in 72/452 subjects (16%). Increasing age was strongly associated with MBL (P-trend
This work was financially supported by the following grants: Red Temática de Investigación Cooperativa en Cáncer del Instituto de Salud Carlos III - FONDOS FEDER (RD06/0020/0035, 2006-RET2039-O, CIBERESP 06/02/0073); FIS PI06/0824-FEDER, PS09/02430-FEDER and PI11/01810-FEDER, from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain; GRS206/A/08 from the Gerencia Regional de Salud de Castilla y León and Ayuda al Grupo GR37 de Excelencia de Castilla y León, Consejería de Educación, and SAN/1778/2009, Consejería de Sanidad, Junta de Castilla y León, Valladolid, Spain; and Agència de Gestió d’Ajuts Universitaris i de Recerca Generalitat de Catalunya (AGAUR 2009SGR1465). AR-C is supported by a grant from Fundación Científica de la Asociación Española contra el Cáncer.
Databáze: OpenAIRE
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