Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis
| Autor: | C. Gastón Bisig, Luciana Previato de Almeida, Chih-Ying Lee, Michael E. Dresser, Michael M. Conrad, Roberto J. Pezza, Yanina Ditamo |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Saccharomyces cerevisiae Proteins LINC COMPLEX Nuclear Envelope LINC complex LIVE IMAGING Myosin Type V Regulator Saccharomyces cerevisiae Biology Prophase General Biochemistry Genetics and Molecular Biology Article purl.org/becyt/ford/1 [https] 03 medical and health sciences NUCLEAR ENVELOPE 0302 clinical medicine Meiosis YEAST TELOMERE-LED RAPID CHROMOSOME MOVEMENTS Cytoskeleton purl.org/becyt/ford/1.6 [https] S. CEREVISIAE Myosin Heavy Chains Chromosome Membrane Proteins Nuclear Proteins Telomere Actin cytoskeleton MEIOSIS Cell biology Actin Cytoskeleton 030104 developmental biology Chromosomes Fungal General Agricultural and Biological Sciences 030217 neurology & neurosurgery |
| Zdroj: | Curr Biol CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | Telomere-led rapid chromosome movements or rapid prophase movements direct fundamental meiotic processes required for successful haploidization of the genome. Critical components of the machinery that generates rapid prophase movements are unknown, and the mechanism underlying rapid prophase movements remains poorly understood. We identified S. cerevisiae Mps2 as the outer nuclear membrane protein that connects the LINC complex with the cytoskeleton. We also demonstrate that the motor Myo2 works together with Mps2 to couple the telomeres to the actin cytoskeleton. Further, we show that Csm4 interacts with Mps2 and is required for perinuclear localization of Myo2, implicating Csm4 as a regulator of the Mps2-Myo2 interaction. We propose a model in which the newly identified functions of Mps2 and Myo2 cooperate with Csm4 to drive chromosome movements in meiotic prophase by coupling telomeres to the actin cytoskeleton. Fil: Lee, Chih Ying. Oklahoma Medical Research Foundation; Estados Unidos Fil: Bisig, Carlos Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Conrad, Michael M.. Oklahoma Medical Research Foundation; Estados Unidos Fil: Ditamo, Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Previato de Almeida, Luciana. Oklahoma Medical Research Foundation; Estados Unidos Fil: Dresser, Michael E.. Oklahoma Medical Research Foundation; Estados Unidos Fil: Pezza, Roberto J.. Oklahoma Medical Research Foundation; Estados Unidos |
| Databáze: | OpenAIRE |
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