Attempts to generate immunity against Trichostrongylus colubriformis and Haemonchus contortus in young lambs by vaccination with viable parasites
| Autor: | David Emery, T. Bendixsen, S.J. McClure, R.J Davey |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Cellular immunity Veterinary medicine Trichostrongylus Antibodies Helminth Helminthiasis Sheep Diseases Biology Lymphocyte Activation Weight Gain Cell Degranulation Feces Immune system Immunity parasitic diseases medicine Animals Mast Cells Anthelmintic Parasite Egg Count Sheep Vaccination Trichostrongylosis medicine.disease biology.organism_classification Infectious Diseases Immunology Female Haemonchus Parasitology Haemonchiasis medicine.drug Haemonchus contortus |
| Zdroj: | International Journal for Parasitology. 28:739-746 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/s0020-7519(98)00040-x |
| Popis: | The ability of young Merino lambs to achieve protective immunity following vaccination via viable nematode infections was assessed. Lambs were infected from 1 month of age by repeated continuous low dose (trickle) administration of Trichostrongylus colubriformis or Haemonchus contortus infective larvae (L3), or by truncated infections with high doses of viable T. colubriformis L3. After 7 weeks all groups were drenched with anthelmintic and at 3 months of age they were re-infected with the homologous species. Protection was assessed by faecal egg counts at 3, 4, 5, 6 and 7 weeks after challenge, and worm count at 7 weeks after challenge. Young lambs were partially protected by 3 months of age against Trichostrongylus by trickle infection. This protection correlated with local mast cell and T-cell priming, increased numbers of local antigen-presenting cells and T-cells and increased worm-specific antibody titres in the intestine. However, there was no evidence that young lambs were capable of immunologically recognising H. contortus antigens following trickle infection, nor did trickle infection significantly protect young lambs against Haemonchus challenge. |
| Databáze: | OpenAIRE |
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