A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss
| Autor: | C E Wright, Kenneth C. H. Fearon, Stephen J. Wigmore, C S McArdle, Donald C. McMillan, Patricia O'Gorman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Palliative care gastrointestinal cancer Appetite Appetite Stimulants Nutritional Status Ibuprofen Placebo Gastroenterology chemistry.chemical_compound Weight loss Internal medicine acute phase response Weight Loss Medicine Humans Prospective Studies prospective randomized study Aged Gastrointestinal Neoplasms Aged 80 and over Performance status business.industry Megestrol Acetate Anti-Inflammatory Agents Non-Steroidal Palliative Care Regular Article Middle Aged Combined Modality Therapy Surgery Regimen C-Reactive Protein Treatment Outcome Oncology chemistry Megestrol acetate Megestrol Quality of Life Female medicine.symptom business medicine.drug |
| Zdroj: | British Journal of Cancer McMillan, D C, Wigmore, S J, Fearon, K C, O'Gorman, P, Wright, C E & McArdle, C S 1999, ' A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss ', British Journal of Cancer, vol. 79, no. 3-4, pp. 495-500 . https://doi.org/10.1038/sj.bjc.6690077 |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6690077 |
| Popis: | The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4–6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P < 0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P < 0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted. © 1999 Cancer Research Campaign |
| Databáze: | OpenAIRE |
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