Long-term survival in a patient with node-positive adult-onset Xp11.2 translocation renal cell carcinoma
| Autor: | Naoto Kuroda, Nobuo Shinohara, Katsuya Nonomura, Kanako Kubota-Chikai, Toshiki Aoyagi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Xp11.2 translocation Urology medicine.medical_treatment Chromosomal translocation Malignancy Nephrectomy Disease-Free Survival Translocation Genetic Retroperitoneal lymph node dissection Renal cell carcinoma Transcription factor E3 Fluorodeoxyglucose F18 Recurrence Internal medicine medicine Carcinoma Humans Lymph node Carcinoma Renal Cell Chromosome Aberrations Chromosomes Human X business.industry Lymphadenectomy medicine.disease Kidney Neoplasms Surgery medicine.anatomical_structure Treatment Outcome Female Lymph Nodes Radiopharmaceuticals business |
| Zdroj: | Urologia internationalis. 86(4) |
| ISSN: | 1423-0399 |
| Popis: | Adult-onset Xp11.2 translocation renal cell carcinoma is a rare malignancy that has an aggressive clinical course and poor prognosis. The reasons for this include the fact that most patients have an advanced clinical stage at diagnosis and also that there is a lack of effective systemic therapy. We herein present the case of a 32-year-old woman suffering from node-positive Xp11.2 translocation renal cell carcinoma who underwent radical nephrectomy with an extensive retroperitoneal lymph node dissection, followed by two times of surgical resection for recurrent nodal disease. The patient has experienced no recurrent disease 4.5 years after the last operation and remains free of disease. Surgical approach to recurrent disease, if the recurrent site can be judged to be limited, might be one of the feasible treatment options in patients with Xp11.2 translocation renal cell carcinoma. |
| Databáze: | OpenAIRE |
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