Crosstalk between mechanotransduction and metabolism
| Autor: | Lorea Valcarcel-Jimenez, Christian Frezza, Patrizia Romani, Sirio Dupont |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cellular differentiation
metabolism signalling cell adhesion mechanotransduction mechanobiology Mechanotransduction Cellular Extracellular matrix 03 medical and health sciences 0302 clinical medicine Cell Adhesion Animals Homeostasis Humans Mechanotransduction Cell adhesion Molecular Biology 030304 developmental biology 0303 health sciences Chemistry Cell Differentiation Cell Biology Metabolism Extracellular Matrix Cell biology Metabolic pathway Crosstalk (biology) Metabolic Networks and Pathways 030217 neurology & neurosurgery |
| Zdroj: | Nature Reviews Molecular Cell Biology. 22:22-38 |
| ISSN: | 1471-0080 1471-0072 |
| DOI: | 10.1038/s41580-020-00306-w |
| Popis: | Mechanical forces shape cells and tissues during development and adult homeostasis. In addition, they also signal to cells via mechanotransduction pathways to control cell proliferation, differentiation and death. These processes require metabolism of nutrients for both energy generation and biosynthesis of macromolecules. However, how cellular mechanics and metabolism are connected is still poorly understood. Here, we discuss recent evidence indicating how the mechanical cues exerted by the extracellular matrix (ECM), cell-ECM and cell-cell adhesion complexes influence metabolic pathways. Moreover, we explore the energy and metabolic requirements associated with cell mechanics and ECM remodelling, implicating a reciprocal crosstalk between cell mechanics and metabolism. |
| Databáze: | OpenAIRE |
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