HtrA Serine Proteases as Potential Therapeutic Targets in Cancer
Autor: | Alfonso Baldi, Mara Campioni, Jeremy Chien, Viji Shridhar |
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Přispěvatelé: | Chien, J, Campioni, M, Shirdhar, V, Baldi, Alfonso |
Rok vydání: | 2009 |
Předmět: |
Cancer Research
Programmed cell death Proteases Gene Expression Antineoplastic Agents Apoptosis Biology Models Biological complex mixtures Article Epigenesis Genetic C5-convertase Serine Drug Delivery Systems Neoplasms Drug Discovery Humans Pharmacology Serine Endopeptidases Sequence Analysis DNA bacterial infections and mycoses Cell biology Oncology HtrA serine peptidase 2 HTRA1 bacteria Apoptosis Regulatory Proteins Epigenetic therapy |
Zdroj: | Current Cancer Drug Targets. 9:451-468 |
ISSN: | 1568-0096 |
DOI: | 10.2174/156800909788486704 |
Popis: | The human HtrA family of serine proteases consists of four members: HtrA1, HtrA2, HtrA3 and HtrA4. Although prokaryotic HtrA proteins are well characterized in their dual roles as chaperones and proteases that degrade misfolded proteins in the periplasm, some members of mammalian HtrA proteins are described as potential modulators of programmed cell death and chemotherapy-induced cytotoxicity. Goal of this review article is to describe the molecular alterations associated with these HtrA serine proteases and how these alterations may be associated with tumor behavior and response to chemotherapy. We will also discuss evidence that chemotherapeutic drugs regulate the expression and activation of HtrA serine proteases and that these proteases contributes to programmed cell death. Finally, we will discuss the potential role of epigenetic therapy in targeting the expression and activation of HtrA serine proteases and the mechanisms by which these proteases enhance cytotoxic effect of conventional chemotherapy. © 2009 Bentham Science Publishers Ltd. |
Databáze: | OpenAIRE |
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