Mechanisms of stable lipid loss in a social insect
| Autor: | Marsha M. Wheeler, Gene E. Robinson, S. Peir Johnson, Scott E. Nixon, Seth A. Ament, Queenie W. Chan, Sandra L. Rodriguez-Zas, Leonard J. Foster |
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| Rok vydání: | 2011 |
| Předmět: |
Queen mandibular pheromone
Physiology Aquatic Science Biology Pheromones Vitellogenins Vitellogenin RNA interference Gene expression Animals Molecular Biology Gene Research Articles Ecology Evolution Behavior and Systematics Regulation of gene expression fungi Gene Expression Regulation Developmental Lipid metabolism Bees Lipid Metabolism Diet Cell biology Biochemistry Insect Science Juvenile hormone behavior and behavior mechanisms biology.protein Insect Proteins RNA Interference Animal Science and Zoology Transcriptome |
| Zdroj: | Journal of Experimental Biology. 214:3808-3821 |
| ISSN: | 1477-9145 0022-0949 |
| DOI: | 10.1242/jeb.060244 |
| Popis: | SUMMARY Worker honey bees undergo a socially regulated, highly stable lipid loss as part of their behavioral maturation. We used large-scale transcriptomic and proteomic experiments, physiological experiments and RNA interference to explore the mechanistic basis for this lipid loss. Lipid loss was associated with thousands of gene expression changes in abdominal fat bodies. Many of these genes were also regulated in young bees by nutrition during an initial period of lipid gain. Surprisingly, in older bees, which is when maximum lipid loss occurs, diet played less of a role in regulating fat body gene expression for components of evolutionarily conserved nutrition-related endocrine systems involving insulin and juvenile hormone signaling. By contrast, fat body gene expression in older bees was regulated more strongly by evolutionarily novel regulatory factors, queen mandibular pheromone (a honey bee-specific social signal) and vitellogenin (a conserved yolk protein that has evolved novel, maturation-related functions in the bee), independent of nutrition. These results demonstrate that conserved molecular pathways can be manipulated to achieve stable lipid loss through evolutionarily novel regulatory processes. |
| Databáze: | OpenAIRE |
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