Cerebral atrophy in AIDS: a stereological study
| Autor: | Bente Pakkenberg, H. J. G. Gundersen, Per Christoffersen, Court Pedersen, Solveig Oster, Jens Ole Nielsen |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Aging AIDS Dementia Complex Stereology Pathology and Forensic Medicine Cerebral Ventricles White matter Cellular and Molecular Neuroscience Cerebellum Basal ganglia Medicine Humans Aged Cerebral atrophy Cerebral Cortex Acquired Immunodeficiency Syndrome Neocortex business.industry Brain Anatomy Middle Aged medicine.disease Cavalieri's principle medicine.anatomical_structure Cerebral cortex Cerebral ventricle Neurology (clinical) Atrophy business Brain Stem |
| Zdroj: | Acta neuropathologica. 85(6) |
| ISSN: | 0001-6322 |
| Popis: | Stereological estimates of mean volumes, surface areas, and cortical thicknesses were obtained on formalin-fixed brains from 19 men with AIDS and 19 controls. Volumes of neocortex, white matter, central brain nuclei, ventricles and archicortex were estimated using point counting and Cavalieri's unbiased principle for volume estimation. In AIDS, the mean volume of neocortex was reduced by 11%, and that of the central brain nuclei by 18%. Mean ventricular volume was increased by 55%. Mean neocortical thickness was reduced by 12%. The mean volume of white matter was reduced by 13%. The findings in 6 clinically demented AIDS patients were not statistically different from the rest of the group. |
| Databáze: | OpenAIRE |
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