IKZF1 rs4132601 and rs11978267 Gene Polymorphisms and Acute Lymphoblastic Leukemia: Relation to Disease Susceptibility and Outcome
| Autor: | Magdy Abd El Moneim El-Ziny, Hosam Abdeltawab, Suzy Abdmabood, Ahmad Darwish, Youssef M. Mosaad, Iman M. Fawzy, Doa M. Sherif, Mohammad Al-Harrass, Mostafa G. Yakoub |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Polymorphism Single Nucleotide Gastroenterology law.invention Cohort Studies Ikaros Transcription Factor 03 medical and health sciences 0302 clinical medicine Risk Factors law Polymorphism (computer science) Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Humans Medicine Genetic Predisposition to Disease Risk factor Child Polymerase chain reaction business.industry Haplotype Hematology Odds ratio Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Survival Rate Oncology Case-Control Studies 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Cohort Adult Acute Lymphoblastic Leukemia Female business Follow-Up Studies 030215 immunology |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 42:420-428 |
| ISSN: | 1077-4114 |
| Popis: | (IKZF1) rs4132601 and rs11978267 are common gene polymorphisms and have been associated with the risk of acute lymphoblastic leukemia. However, these associations are less evident in races and/or ethnicities other than European and Hispanic. Therefore, we investigated the association between these single-nucleotide polymorphisms and acute lymphoblastic leukemia susceptibility and disease outcome. Real-time polymerase chain reaction typing was performed for IKZF1 rs4132601 and rs11978267 for 128 pediatric acute lymphoblastic leukemia (pALL), 45 adult acute lymphoblastic leukemia (aALL), and 436 healthy controls. The G allele-containing and G-containing genotypes (GG+GT) of rs4132601 were significantly higher in pALL (P=0.003, odds ratio [OR]=1.65, 0.009, OR=1.42, respectively) and aALL (P=0.016, OR=1.81 and 0.011, OR=1.61, respectively). However, the GG haplotype was associated with the risk of pALL (P=0.044), the GA haplotype was associated with the risk of aALL (P=0.007). In aALL, the GG genotype of rs4132601 was associated with absence of remission and poor overall survival (P=0.003 and 0.041, respectively). The IKZF1 rs4132601 single-nucleotide polymorphism can be considered a susceptibility risk factor for the development of pALL and aALL in the studied cohort of Egyptian patients. The GG genotype of IKZF1 rs4132601 may be a risk factor for poor outcome in aALL patients. |
| Databáze: | OpenAIRE |
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