Development of human papillomavirus-associated Buschke-Löwenstein penile carcinoma during cyclosporine therapy for generalized pustular psoriasis
| Autor: | Glenna C. Burmer, Michael W. Piepkorn, John N. Krieger, Brian Kumasaka |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Time Factors Penile Neoplasm Dot blot Dermatology Polymerase Chain Reaction Virus Pathogenesis Psoriasis Penile Carcinoma medicine Humans DNA Probes HPV Papillomaviridae Penile Neoplasms biology business.industry medicine.disease biology.organism_classification Tumor Virus Infections Condylomata Acuminata Cyclosporine Generalized pustular psoriasis business |
| Zdroj: | Journal of the American Academy of Dermatology. 29:321-325 |
| ISSN: | 0190-9622 |
| Popis: | Buschke-Löwenstein-type giant penile condyloma developed in a human immunodeficiency virus-negative, 25-year-old man after 4 years of intermittent cyclosporine therapy (5 mg/kg/day) for pustular psoriasis. Microscopic examination showed multifocal areas of invasive squamous cell carcinoma. Dot blot analysis of amplified polymerase chain reaction products with primers directed at the L1 region demonstrated signals for several human papillomavirus genotypes, including human papillomavirus type 16, that correlated with different histologic patterns consisting of verrucous and bowenoid changes and invasive carcinoma. This case conforms to the enhanced risk of cutaneous carcinogenesis from either papillomavirus infection or chronic actinic damage that has become evident in patients with organ allografts and cyclosporine therapy. |
| Databáze: | OpenAIRE |
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