Herbicidal aryldiones incorporating a 5-methoxy-[1,2,5]triazepane ring
| Autor: | Sophie Oliver, Danielle Sayer, Nigel James Willetts, Caroline Thompson, Tomas Smejkal, Laura Wildsmith, Shuji Hachisu, James Nicholas Scutt, Michel Muehlebach |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Clinical Biochemistry Hydrazine Pharmaceutical Science Ether Ring (chemistry) 01 natural sciences Biochemistry Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Drug Discovery Moiety Enzyme Inhibitors Binding site Molecular Biology Dose-Response Relationship Drug Molecular Structure Herbicides 010405 organic chemistry Organic Chemistry Ketones Combinatorial chemistry 0104 chemical sciences 030104 developmental biology chemistry Molecular Medicine Bioisostere Enzyme inhibitory Acetyl-CoA Carboxylase |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 28:339-343 |
| ISSN: | 0960-894X |
| Popis: | Novel 2-aryl-cyclic-1,3-diones containing a 5-methoxy-[1,2,5]triazepane unit were explored towards an effective and wheat safe control of grass weeds. Their preparation builds on the ease of synthetic access to 7-membered heterocyclic [1,2,5]triazepane building blocks. Substitution and pattern hopping in the phenyl moiety revealed structure–activity relationships in good agreement with previously disclosed observations amongst the pinoxaden family of acetyl-CoA carboxylase inhibitors. In light of basic physicochemical, enzyme inhibitory and binding site properties, the N-methoxy functionality effectively acts as a bioisostere of the ether group in the seven-membered hydrazine ring. |
| Databáze: | OpenAIRE |
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