Chemical investigation of different crude extracts from Teucrium ramosissimum leaves. Correlation with their antigenotoxic and antioxidant properties
| Autor: | Ines Skandrani, Ines Bouhlel, M. Ben Sghaier, Wissem Bhouri, Aicha Neffati, Leila Chekir-Ghedira, Jihed Boubaker, Soumaya Kilani, Kamel Ghedira |
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| Rok vydání: | 2011 |
| Předmět: |
Xanthine Oxidase
Aflatoxin B1 Antioxidant medicine.medical_treatment Toxicology medicine.disease_cause Antioxidants Teucrium chemistry.chemical_compound Escherichia coli medicine Food science SOS response SOS Response Genetics Xanthine oxidase biology Plant Extracts Antimutagenic Agents Biological activity General Medicine biology.organism_classification Xanthine Plant Leaves SOS chromotest Nitrofurantoin chemistry Biochemistry Genotoxicity Mutagens Food Science |
| Zdroj: | Food and Chemical Toxicology. 49:191-201 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2010.10.016 |
| Popis: | The effect of extracts obtained from Teucrium ramosissimum leaves on genotoxicity and SOS response induced by aflatoxin B 1 (0.5 μg/assay) as well as nitrofurantoin (5 μg/assay) was investigated in a bacterial assay system, i.e., the SOS chromotest with Escherichia coli PQ37. The T. ramosissimum tested extracts exhibited no genotoxicity either with or without the external S9 activation mixture. However, all the extracts, particularly the total oligomers flavonoids (TOF) extract significantly decreased the genotoxicity induced by aflatoxin B 1 and nitrofurantoin. Antioxidant capacity of the tested extracts was evaluated using the enzymatic (xanthine/xanthine oxidase assay) (X/XOD) and the non-enzymatic (NBT/Riboflavine assay) systems. TOF extract was the most effective one in inhibiting both xanthine oxidase activity and NBT reduction. Our findings emphasize the potential of T. ramosissimum to prevent mutations and also its antioxidant effect. |
| Databáze: | OpenAIRE |
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