Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents
| Autor: | Hiroshi Sasaki, Eri Kubo, Sachiko Kodera, Natsuko Hatsusaka, Naoki Yamamoto, Akimasa Hirata, Fumiaki Miura, Essam A. Rashed |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
FOS: Computer and information sciences
0301 basic medicine Nuclear cataract Ultraviolet Rays Computer Vision and Pattern Recognition (cs.CV) Wet-bulb globe temperature Computer Science - Computer Vision and Pattern Recognition FOS: Physical sciences Health Informatics Cataract 03 medical and health sciences Computer Science - Computers and Society 0302 clinical medicine Cataracts Risk Factors Computers and Society (cs.CY) Prevalence Humans Medicine Elderly people Ultraviolet radiation Aged business.industry medicine.disease Physics - Medical Physics Computer Science Applications 030104 developmental biology Time course Weather data Medical Physics (physics.med-ph) Thermal dose business 030217 neurology & neurosurgery Demography |
| Popis: | Recent epidemiological studies have hypothesized that the prevalence of cortical cataracts is closely related to ultraviolet radiation. However, the prevalence of nuclear cataracts is higher in elderly people in tropical areas than in temperate areas. The dominant factors inducing nuclear cataracts have been widely debated. In this study, the temperature increase in the lens due to exposure to ambient conditions was computationally quantified in subjects of 50-60 years of age in tropical and temperate areas, accounting for differences in thermoregulation. A thermoregulatory response model was extended to consider elderly people in tropical areas. The time course of lens temperature for different weather conditions in five cities in Asia was computed. The temperature was higher around the mid and posterior part of the lens, which coincides with the position of the nuclear cataract. The duration of higher temperatures in the lens varied, although the daily maximum temperatures were comparable. A strong correlation (adjusted R2 > 0.85) was observed between the prevalence of nuclear cataract and the computed cumulative thermal dose in the lens. We propose the use of a cumulative thermal dose to assess the prevalence of nuclear cataracts. Cumulative wet-bulb globe temperature, a new metric computed from weather data, would be useful for practical assessment in different cities. Submitted to Computers in Biology and Medicine |
| Databáze: | OpenAIRE |
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