Infusion of iso-rANP(1-45) or (17-45) increases plasma immunoreactive ANP and lowers plasma renin activity and aldosterone
| Autor: | J. C. McKirdy, T.G. Flynn, I. R. Sarda, G. K. Hira, D. B. Jennings, P. J. Ohtake |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Vasopressin medicine.medical_specialty Physiology Molecular Sequence Data Stimulation Peptide hormone Plasma renin activity chemistry.chemical_compound Dogs Atrial natriuretic peptide Physiology (medical) Internal medicine Renin–angiotensin system Renin medicine Animals Amino Acid Sequence Receptor Aldosterone Pharmacology Osmolar Concentration Sodium General Medicine Peptide Fragments Arginine Vasopressin Endocrinology chemistry cardiovascular system Female hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor circulatory and respiratory physiology |
| Zdroj: | Canadian journal of physiology and pharmacology. 68(9) |
| ISSN: | 0008-4212 |
| Popis: | We have reported that a second rat atrial natriuretic peptide, iso-rANP(1–45), as well as the putative ANP homologue, iso-rANP(17–45), elicited circulatory and renal responses in the rat similar to those found after administration of ANP. Iso-rANP also interacted with ANP to potentiate the observed biological activity in the rat. In the present studies in awake dogs, intravenous infusion of low doses (6.3–50 pmol∙kg−1∙min−1) of iso-rANP(1–45) and iso-rANP(17–45) increased plasma immunoreactive ANP and suppressed plasma renin activity (PRA) and aldosterone. Iso-rANP, like ring-deleted analogues of ANP, may have displaced ANP from ANP clearance receptors to increase plasma ANP concentration, since factors influencing myocardial ANP release were not changed. The effect of iso-rANP(1–45) and (17–45) in lowering PRA and plasma aldosterone may therefore have been indirect, via ANP stimulation of active guanylate cyclase-linked ANP receptors. However, an additional direct effect of iso-rANP on an active receptor cannot be excluded.Key words: clearance and active ANP receptors, arginine vasopressin, water and electrolyte balance, circulatory hemodynamics. |
| Databáze: | OpenAIRE |
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