Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia
| Autor: | Mahmoud Mohamed Elgari, Omar F. Khabour, Elharam Ibrahim Abdallah, Abdel Rahim Mahmoud Muddathir, Ream Elzain Abdelgader |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Sudan 0302 clinical medicine Genotype CML Glutathione Transferase Aged 80 and over education.field_of_study GSTT1 lcsh:R5-920 biology integumentary system Age Factors Myeloid leukemia General Medicine Middle Aged Leukemia Glutathione S-transferase 030220 oncology & carcinogenesis Female lcsh:Medicine (General) Research Article Adult Adolescent Population 03 medical and health sciences Young Adult Sex Factors Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans education Genotyping neoplasms glutathione S-transferase Aged Polymorphism Genetic business.industry Haplotype Case-control study GSTs medicine.disease null polymorphism 030104 developmental biology Case-Control Studies Immunology biology.protein business GSTM1 |
| Zdroj: | Bosnian Journal of Basic Medical Sciences (2019) |
| Popis: | The glutathione S-transferase (GST) genes encode enzymes that mediate the detoxification of xenobiotics by catalyzing the conjugation of glutathione (GSH) to xenobiotic substrates. The aim of the current study is to investigate the association between GSTT1 and GSTM1 polymorphisms and chronic myeloid leukemia (CML) among Sudanese patients. Patients with CML (n = 115) were recruited to the study from the Radiation and Isotope Centre Khartoum (RICK)-Sudan. Healthy individuals (n = 104) were included as controls. Genotyping of GSTT1 and GSTM1 polymorphisms was performed using multiplex PCR. Null deletions in the GSTT1 and GSTM1 genes are common in the Sudanese population (control group), with frequencies of 33.9% and 38.2%, respectively. The frequencies of GSTT1 (OR: 3.25, 95% CI: 1.87–5.65, p < 0.001) and GSTM1 (OR: 2.14, 95% CI: 1.25–3.67, p < 0.005) null genotypes were significantly higher in CML patients vs. controls. The distribution of GSTT1 and GSTM1 null polymorphisms was not different between male and female (p > 0.01) and young and old CML patients (p > 0.05). Hematological parameters were not affected by null polymorphisms in the patient group (p > 0.05). In addition, the frequency of GSTM1 null polymorphism was lower in advanced-phase CML patients compared to chronic-phase patients (p < 0.05). The GSTT1 and GSTM1 null polymorphisms are associated with CML among Sudanese patients, independently of their age and gender. |
| Databáze: | OpenAIRE |
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