Screening Method for the Quality Evaluation of Cannabidiols in Water-based Products Using Liquid Chromatography Tandem Mass Spectrometry
| Autor: | Shiori Takashina, Yuki Igarashi, Koichi Inoue, Yukie Kondo, Miki Takahashi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Electrospray
Cannabigerol 02 engineering and technology Tandem mass spectrometry 01 natural sciences Analytical Chemistry chemistry.chemical_compound Limit of Detection Tandem Mass Spectrometry Liquid chromatography–mass spectrometry Food Quality medicine Cannabidiol Detection limit Chromatography 010401 analytical chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Cannabinol Methanol Mineral Waters 0210 nano-technology Food Analysis Chromatography Liquid medicine.drug |
| Zdroj: | Analytical Sciences. 36:1427-1430 |
| ISSN: | 1348-2246 0910-6340 |
| DOI: | 10.2116/analsci.20n015 |
| Popis: | A sensitive, useful and preliminary screening method was proposed to quantitate the containable cannabinoids most commonly included in mineral water and gummi candy products, specifically cannabidiol (CBD), cannabinol (CBN), 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCA), cannabigerol (CBG), and cannabidiolic acid (CBDA), using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) for quality evaluations. Based on the electrospray positive ion mode, the limit of detection and the limit of quantification values were 0.2 to 0.5 ng/mL and 0.8 and 2.0 ng/mL. Samples (0.5 g) were diluted by water/methanol (50/50), to which stable isotope internal standards were added; the recovery results appeared in range from 91.3 to 101.2%. This method was applied to evaluate CBD products (6 kinds) from the Japanese market. Our survey found obvious discrepancies between the labeling and the results were overserved in products. In addition, CBN, THCA, CBG, and CBDA were not detected in full-spectrum products that contained various cannabinoids that naturally occur in the cannabis plant. Thus, it is necessary to be able to verify the accurate concentration and impurity in various CBD products from the Japanese market as quickly as possible. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink