Experimental validation of the filtering approach for dose monitoring in proton therapy at low energy
| Autor: | F. Di Rosa, M. Camarda, Nicola Belcari, Valeria Rosso, G.A.P. Cirrone, S. Moehrs, Nico Lanconelli, A. Del Guerra, Giorgio Ivan Russo, F. Attanasi, Sara Vecchio |
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| Přispěvatelé: | F. Attanasi, N. Belcari, M. Camarda, A. Del Guerra, S. Moehr, V. Rosso, S. Vecchio, N. Lanconelli, G.A.P. Cirrone, F. Di Rosa, G. Russo |
| Rok vydání: | 2008 |
| Předmět: |
Nuclear reaction
Physics::Medical Physics Monte Carlo method Biophysics General Physics and Astronomy Signal Biophysical Phenomena Convolution Neoplasms Proton Therapy medicine Humans Radiology Nuclear Medicine and imaging Proton therapy Physics Range (particle radiation) medicine.diagnostic_test Radiotherapy Planning Computer-Assisted Radiotherapy Dosage General Medicine Models Theoretical Computational physics Positron emission tomography Positron-Emission Tomography Beam (structure) Biomedical engineering |
| Zdroj: | Physica Medica. 24:102-106 |
| ISSN: | 1120-1797 |
| DOI: | 10.1016/j.ejmp.2008.03.001 |
| Popis: | The higher physical selectivity of proton therapy demands higher accuracy in mon- itoring of the delivered dose, especially when the target volume is located next to critical or- gans and a fractionated therapy is applied. A method to verify a treatment plan and to ensure the high quality of the hadrontherapy is to use Positron Emission Tomography (PET), which takes advantage of the nuclear reactions between protons and nuclei in the tissue during irra- diation producing b þ -emitting isotopes. Unfortunately, the PET image is not directly propor- tional to the delivered radiation dose distribution; this is the reason why, at the present time, the verification of depth dose profiles with PET techniques is limited to a comparison between the measured activity and the one predicted for the planned treatment by a Monte Carlo model. In this paper we test the feasibility of a different scheme, which permits to re- construct the expected PET signal from the planned radiation dose distribution along beam di- rection in a simpler and more direct way. The considered filter model, based on the description of the PET image as a convolution of the dose distribution with a filter function, has already demonstrated its potential applicability to beam energies above 70 MeV. Our experimental investigation provides support to the possibility of extending the same approach to the lower energy range ((40, 70) MeV), in the perspective of its clinical application in eye proton therapy. a 2008 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica. |
| Databáze: | OpenAIRE |
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