Surgically Treated Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck: Outcome Predictors and the Role of Adjuvant Radiation Therapy

Autor: Gilad Horowitz, Orit Gutfeld, Liyona Kampel, Nidal Muhanna, Alexandra Dorman, Dan M. Fliss
Rok vydání: 2021
Předmět:
Male
medicine.medical_specialty
Skin Neoplasms
Cutaneous squamous cell carcinoma
medicine.medical_treatment
Nose Neoplasms
Kaplan-Meier Estimate
Multimodality Therapy
Eyelid Neoplasms
Disease-Free Survival
Immunocompromised Host
medicine
Humans
Parotid Gland
Neoplasm Invasiveness
Forehead
Head and neck
Ear Neoplasms
Aged
Proportional Hazards Models
Aged
80 and over
Extranodal Extension
Adjuvant radiotherapy
Scalp
Squamous Cell Carcinoma of Head and Neck
business.industry
Margins of Excision
Neck dissection
Chemoradiotherapy
Adjuvant
General Medicine
Middle Aged
Plastic Surgery Procedures
Otorhinolaryngologic Surgical Procedures
Survival Rate
Cheek
Treatment Outcome
Otorhinolaryngology
Lip Neoplasms
Risk stratification
Neck Dissection
Female
Radiotherapy
Adjuvant
Lymph Nodes
Radiology
Facial Neoplasms
Neoplasm Grading
Neoplasm Recurrence
Local
business
Zdroj: Annals of Otology, Rhinology & Laryngology. 130:1016-1023
ISSN: 1943-572X
0003-4894
DOI: 10.1177/0003489421990182
Popis: Objectives: Advanced cutaneous squamous cell carcinoma of the head and neck (CSCCHN) is associated with poor outcome despite multimodality therapy. Comprehensive risk stratification may pinpoint the most suitable adjuvant treatment. This study aimed to evaluate the outcomes of surgically treated locoregional CSCCHN and to identify prognostic indicators of treatment outcomes. Methods: We retrospectively analyzed disease variables, pathologic characteristics, and management in association with treatment outcomes of all consecutive advanced CSCCHN patients who underwent surgical resection at Tel Aviv Sourasky Medical Center. Results: From 2008 to 2018, 74 patients met the inclusion criteria. Only perineural invasion (PNI) was significantly associated with worse overall survival (OS) ( P = .001). Location within the facial “mask areas” was significantly associated with pathologically negative cervical disease ( P = .001). Forty-seven patients underwent adjuvant radiation therapy (RT) which significantly improved OS and disease-free survival versus surgery alone ( P = .025 and P = 0.035, respectively). Conclusion: PNI was associated with worse OS in surgically treated advanced CSCCHN. Adjuvant RT conferred better outcomes despite high risk features.
Databáze: OpenAIRE
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