Neurocognitive and behavioural performance of healthy volunteers receiving an increasing analgesic-range infusion of ketamine
| Autor: | Yahya Shehabi, Panagiota Kostakis, Luke A. Downey, Michael Keane, Maja Green, Amie C. Hayley |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Post hoc Visual analogue scale Analgesic Young Adult 03 medical and health sciences Cognition 0302 clinical medicine Bolus (medicine) Healthy volunteers Reaction Time medicine Humans Ketamine Infusions Intravenous Pharmacology Analgesics Behavior business.industry Cambridge Neuropsychological Test Automated Battery 030227 psychiatry Memory Short-Term Anesthesia Female business Neurocognitive Psychomotor Performance 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychopharmacology. 235:1273-1282 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-018-4842-7 |
| Popis: | The acute and delayed effect of analgesic-range doses of ketamine on neurocognitive and behavioural outcomes is understudied. Using a non-controlled open-labelled design, three (1-h duration) increasing intravenous (IV) ketamine infusions comprising (i) 30 mg bolus of ketamine + 8 mg/h IV infusion, (ii) 12 mg/h IV infusion and (iii) 20 mg/h infusion were administered to 20 participants (15 male, 5 female, mean age = 30.8 years). Whole-blood ketamine and norketamine concentrations were determined at each treatment step and post-infusion. The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to assess reaction/movement time (RTI, Simple and 5-Choice), visuospatial working memory (SWM), spatial planning (SOC) and subjective effects (visual analogue scale; VAS) during treatment and at post-treatment. Significant main effects were reported for time (dose) on CANTAB RTI 5-Choice reaction (F(4,18) = 3.41, p = 0.029) and movement time (F(4,18) = 4.42, p = 0.011), SWM (F(4,18) = 4.19, p = 0.014) and SOC (F(4,18) = 4.13, p = 0.015), but not RTI Simple reaction or movement time. Post hoc analyses revealed dose-dependent effects for both RTI 5-Choice reaction and movement time (all p |
| Databáze: | OpenAIRE |
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