Effects of Oral Magnesium Supplementation on Vascular Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials
| Autor: | Michelle Rabello Cunha, Lívia de Paula Nogueira, Flávia Miranda Corrêa, Márcia Regina Simas Torres Klein, Bianca Cristina Antunes Alves Marques, Tainah de Paula, Wille Oigman, Samanta de Souza Mattos, Mario Fritsch Neves |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Time Factors Health Status Administration Oral Cochrane Library Overweight Body Mass Index law.invention 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Pharmacotherapy Randomized controlled trial Risk Factors law Internal medicine Internal Medicine medicine Humans Magnesium Obesity Pulse wave velocity Aged Randomized Controlled Trials as Topic business.industry Age Factors Middle Aged medicine.disease Vasodilation Treatment Outcome 030104 developmental biology Cardiovascular Diseases Meta-analysis Dietary Supplements Arterial stiffness Female Endothelium Vascular medicine.symptom Cardiology and Cardiovascular Medicine business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | High Blood Pressure & Cardiovascular Prevention. 27:19-28 |
| ISSN: | 1179-1985 1120-9879 |
| DOI: | 10.1007/s40292-019-00355-z |
| Popis: | The effects of magnesium (Mg) supplementation on vascular function have been evaluated in some randomized controlled trials (RCT) but their results are conflicting. A systematic review and meta-analysis were conducted to summarize the effects of oral Mg supplementation on vascular function in RCT. The databases MEDLINE (PubMed), Embase, Web of Science and Cochrane Library were accessed from inception to May 27, 2019. Intergroup differences (treatment vs. control group) related to changes in flow-mediated dilation (FMD) and pulse wave velocity (PWV), expressed as mean and standard deviation, were used to evaluate the effect of Mg supplementation on these outcomes. The results of the meta-analysis were expressed using a random-effects model. The heterogeneity between studies was evaluated using the I2 statistic. The oral supplementation of Mg had no significant effect on FMD (mean difference 2.13; 95% CI − 0.56, 4.82; p = 0.12) and PWV (mean difference − 0.54, 95% CI − 1.45, 0.36, p = 0.24). Heterogeneity for both outcomes (FMD and PWV) was high (I2 = 99%, p |
| Databáze: | OpenAIRE |
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