To assess whether addition of pyriproxyfen to long-lasting insecticidal mosquito nets increases their durability compared to standard long-lasting insecticidal mosquito nets: study protocol for a randomised controlled trial

Autor: Hilary Ranson, Alfred B. Tiono, Brian Faragher, Emile Fs Tchicaya, N’Fale Sagnon, Steve W. Lindsay, Margaret Pinder
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Insecticides
Mosquito Control
Time Factors
Pyridines
Anopheles gambiae
Medicine (miscellaneous)
Disease Vectors
law.invention
Toxicology
chemistry.chemical_compound
Study Protocol
Randomized controlled trial
law
Pregnancy
Pharmacology (medical)
2. Zero hunger
Randomised controlled trial
Pyrethroid
biology
Insecticide-treated bed net
Pregnancy Outcome
Temperature
Entomological inoculation rate
3. Good health
Mosquito control
Equipment Failure
Female
Seasons
medicine.drug
Malaria control
wc_765
Net durability
qx_600
parasitic diseases
Clinical malaria
Anopheles
Burkina Faso
medicine
Animals
Humans
Insecticide-Treated Bednets
Insect juvenile hormone mimic
Permethrin
business.industry
wa_240
Humidity
medicine.disease
biology.organism_classification
Malaria
chemistry
Pyriproxyfen
business
Insecticide resistance management
Zdroj: Trials
Trials, 2015, Vol.16(1), pp.195 [Peer Reviewed Journal]
ISSN: 1745-6215
Popis: Background The effectiveness of pyrethroid-treated bednets for malaria control in sub-Saharan Africa is under threat because of high levels of resistance to pyrethroid insecticides in the vectors. Here we assess the durability of polyethylene nets with a novel combination of permethrin, a pyrethroid, with pyriproxyfen, an insect juvenile mimic (PPF-LLIN), in comparison with a typical permethrin-treated long-lasting insecticidal net (LLIN). Methods This is a cluster randomised controlled trial of net durability in Burkina Faso, with clustering at the level of the compound and includes entomological outcome measurements. Half the compounds in each village will be randomly allocated PPF-LLIN and half the LLIN. All sleeping places in a compound will be provided with one type of net. We will distribute the nets at the start of the first transmission season and follow net use at the start and end of each transmission season for 3 years. In one village, bio-efficacy and chemical content will be recorded immediately after net distribution and then at 6, 12, 18, 24, 30 and 36 months. In the other village net survivorship and fabric integrity will be recorded immediately after distribution, and then at 6, 12, 18, 24, 30 and 36 months. Routine measurements of indoor temperature and relative humidity will be made in both villages during the study. Residents will be followed for possible side effects of the PPF-LLIN by surveillance of known asthmatic subjects during the first month post-distribution and pregnancy outcomes will be monitored from antenatal clinic records. Discussion The protocol is novel on two accounts. Firstly, it is the first to describe the procedure for measuring net durability following recent World Health Organisation (WHO) guidelines. Meeting the minimum requirements set in the guidelines is essential before a new type of net can be recommended by WHO’s Pesticide Evaluation Scheme (WHOPES). Secondly, it describes methods to monitor the persistence of an active ingredient that reduces vector fertility and fecundity. If the PPF-LLIN is both effective and persistent it will provide an alternative vector control strategy where pyrethroid-resistant vectors are present. Trial registration ISRCTN30634670 assigned 13 August 2014. Electronic supplementary material The online version of this article (doi:10.1186/s13063-015-0700-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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