Tissue Factor and Tissue Factor Pathway Inhibitor in Chronically Inflamed Gallbladder Mucosa
| Autor: | Jacek Liczko, Grzegorz Wyrobiec, Krzysztof Helewski, Małgorzata Żaba, Dorota Domal-Kwiatkowska, Józef Kurek, Tomasz Stawski, Daniel Sabat, Marek Kucharzewski, Damian Dudek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Article Subject CD3 Complex medicine.medical_treatment Lipoproteins lcsh:Medicine Antigens Differentiation Myelomonocytic Gallbladder Injury Biology General Biochemistry Genetics and Molecular Biology Thromboplastin Tissue factor Tissue factor pathway inhibitor Antigens CD medicine Humans Prospective Studies Inflammation Mucous Membrane General Immunology and Microbiology CD68 Gallbladder lcsh:R General Medicine Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Cholecystitis Cholecystectomy Female Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | We characterised a tissue factor (TF) and tissue factor pathway inhibitor (TFPI) expression in relation to severity of inflammatory infiltration of the gallbladder mucosa in a chronic cholecystitis. We prospectively studied the gallbladder specimens obtained from 54 patients who had undergone cholecystectomy due to chronic calculous cholecystitis and 16 calculosis-free gallbladder specimens obtained from patients who underwent cholecystectomy due to the polyp/polyps as well as in cases of gallbladder injury. To assess TF and TFPI immunoreactivity by immunohistochemistry, the monoclonal anti-human TF and TFPI antibodies were used. The inflammatory infiltration of the gallbladder mucosa was reflected by the number of CD3 and CD68 positive cells. The expression of TF and TFPI differed significantly between the cholecystitis and the control group. Most capillary endothelial cells of the cholecystitis group presented weak expression for TFPI. The mean number of CD3 positive lymphocytes in the cholecystitis group was 18.6 ± 12.2, but the mean number of CD68 positive cells was 29.7 ± 13.9. In the control sections, it was 3.1 ± 1.9 and 8.8 ± 3.9, respectively (P<0.001). The results of the current study suggest that the tissue procoagulant state found may be engaged in the etiopathogenesis of the cholecystitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|