Anti-cancer Activity Profile of 3’-Azidothymidine 5’- [p-Methoxyphenyl Methoxyalaninyl Phosphate] (Compound 003), a Novel Nucleoside Analog
| Autor: | Taracad K. Venkatachalam, Douglas Erbeck, Fatih M. Uckun, Xing-Ping Liu, Sanjive Qazi, Ilker Dibirdik, Heather E. Tibbles, Alexei O. Vassilev |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
G2 Phase
Antineoplastic Agents Mice Transgenic Spindle Apparatus Pharmacology Microtubules Mice Zidovudine Cell Line Tumor Drug Discovery medicine Animals Humans Cytotoxic T cell Oligonucleotide Array Sequence Analysis Centrosome Microscopy Confocal Dose-Response Relationship Drug biology Reverse-transcriptase inhibitor Chemistry Gene Expression Profiling Mammary Neoplasms Experimental Cancer DNA Flow Cytometry Nucleotidyltransferase medicine.disease Blood Cell Count Rats Rats Inbred Lew Enzyme inhibitor Toxicity biology.protein Female Nucleoside Dideoxynucleotides medicine.drug |
| Zdroj: | Arzneimittelforschung. 54:715-731 |
| ISSN: | 1616-7066 0004-4172 |
| DOI: | 10.1055/s-0031-1297029 |
| Popis: | The novel cytotoxic nucleoside analog Compound 003 (3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate], CAS 149560-32-7) prevented bipolar mitotic spindle assembly and caused a G2 arrest in human cancer cells. Compound 003 was very well tolerated by both mice and rats without any toxicity at cumulative dose levels >2 g/kg. Notably, Compound 003 prolonged cancer-free survival in the MMTVneu transgenic mouse model of HER2 positive breast cancer. These results indicate that Compound 003 may be useful in the treatment of cancer patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|