Efficacy of inhaled nitric oxide in oleic acid-induced acute lung injury
| Autor: | Samuel A. Yousem, Timothy R. Billiar, Andrew B. Peitzman, Isuta Nishio, Timothy D. Jacob, Nishit S. Shah, Taiyo Imai, Etsuro K. Motoyama, Renee Exler, Don K. Nakayama |
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| Rok vydání: | 1997 |
| Předmět: |
Swine
Hypertension Pulmonary Vasodilator Agents Lung injury Nitric Oxide Critical Care and Intensive Care Medicine Nitric oxide chemistry.chemical_compound Hypoxic pulmonary vasoconstriction Administration Inhalation medicine Animals Nitrite Respiratory Distress Syndrome Respiratory distress Inhalation Pulmonary Gas Exchange business.industry Respiratory disease medicine.disease Pulmonary hypertension Disease Models Animal chemistry Anesthesia business Oleic Acid |
| Zdroj: | Critical Care Medicine. 25:153-158 |
| ISSN: | 0090-3493 |
| Popis: | Objective: To assess the efficacy of inhaled nitric oxide in improving pulmonary hypertension and gas exchange following oleic acid-induced acute lung injury. Design: Prospective, pharmacologic study. Setting: Surgical research laboratory at the University of Pittsburgh, Pittsburgh, PA. Subjects: Instrumented, intubated pigs weighing 16 to 27 kg. Interventions: Intravenous oleic acid and inhaled nitric oxide. Measurements and Main Results: All pigs treated with intravenous oleic acid (0.11 mUkg) developed a severe lung injury with pulmonary hypertension, accompanied by impaired oxygenation, intrapulmonary shunting, and increased extravascular lung water (p |
| Databáze: | OpenAIRE |
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