Bone marrow metastasis presenting as bicytopenia originating from hepatocellular carcinoma
| Autor: | Hyun Young Woo, Jeong Heo, Young Mi Hong, Cheol Woong Choi, Ki Tae Yoon, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, SM Bakhtiar Ui Islam, Won Lim, Mong Cho |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Case Report Metastasis 03 medical and health sciences 0302 clinical medicine Positron Emission Tomography Computed Tomography Biopsy Carcinoma medicine Humans Bone marrow Neoplasm Metastasis Protein Precursors lcsh:RC799-869 Molecular Biology Lymph node Hepatology medicine.diagnostic_test business.industry Liver Neoplasms Bone metastasis Hepatocellular Middle Aged medicine.disease Thrombocytopenia digestive system diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Hepatocellular carcinoma Prothrombin lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology alpha-Fetoproteins Tomography X-Ray Computed business Biomarkers |
| Zdroj: | Clinical and Molecular Hepatology, Vol 22, Iss 2, Pp 267-271 (2016) Clinical and Molecular Hepatology |
| ISSN: | 2287-285X 2287-2728 |
| DOI: | 10.3350/cmh.2015.0017 |
| Popis: | The bone is a common site for metastasis in hepatocellular carcinoma (HCC). However, bone marrow metastasis from HCC is rarely reported, and its frequency is unclear. Here we report a rare case of bone marrow metastasis that presented as bicytopenia originating from HCC without bone metastasis. A 58-year-old man was admitted for investigation of a liver mass with extensive lymph node enlargement that was detected when examining his general weakness and weight loss. Laboratory findings revealed anemia, thrombocytopenia, mild elevated liver enzymes, normal prothrombin time percentage and high levels of tumor markers (α-fetoprotein and des-γ-carboxyprothrombin). Abdominal computed tomography showed multiple enhanced masses in the liver and multiple enlarged lymph nodes in the abdomen. A bone marrow biopsy revealed only a few normal hematopoietic cells and abundant tumor cells. Despite its rarity, bone marrow metastasis should always be suspected in HCC patients even if accompanied by cirrhosis. |
| Databáze: | OpenAIRE |
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