A general method for N-glycosylation of nucleobases promoted by (p-Tol)2SO/Tf2O with thioglycoside as donor
| Autor: | Xiao-tai Zhang, Guang-jian Liu, Guo-wen Xing |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Glycosylation
General method Stereochemistry Glycoconjugate Stereoisomerism Catalysis Nucleobase chemistry.chemical_compound N-linked glycosylation Materials Chemistry Purine metabolism Mesylates chemistry.chemical_classification Chemistry organic chemicals Metals and Alloys General Chemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials Thioglycosides Sulfoxides Ceramics and Composites bacteria Glycoconjugates |
| Zdroj: | Chemical Communications. 51:12803-12806 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c5cc03617h |
| Popis: | Based on a preactivation strategy using the (p-Tol)2SO/Tf2O system, a series of nucleosides were synthesized by coupling various thioglycosides with pyrimidines and purines under mild conditions. High yields and excellent β-stereoselectivities were obtained with either armed or disarmed N-glycosylation donors by tuning the amount of (p-Tol)2SO additive. |
| Databáze: | OpenAIRE |
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