The Effect of Chemotherapy Dose Intensity on the Hematological Toxicity of the Treatment for Wilmsʼ Tumor
| Autor: | J. Z. Finklestein, I Evans, A E Evans, J Moksness, Norman E. Breslow, Daniel M. Green, Giulio J. D'Angio |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Vincristine Adolescent medicine.medical_treatment Urology Wilms Tumor Antineoplastic Combined Chemotherapy Protocols medicine Humans Doxorubicin Child Chemotherapy Blood Cells Leukopenia business.industry Infant Newborn Infant Wilms' tumor Hematology medicine.disease Kidney Neoplasms Surgery Regimen Oncology Child Preschool Pediatrics Perinatology and Child Health Toxicity Dactinomycin Absolute neutrophil count medicine.symptom business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 16:207-212 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/00043426-199408000-00004 |
| Popis: | Purpose To determine the relationship between hematological toxicity and actual dose intensity of treatment of patients randomized to therapy during the first 28 months of the National Wilms' Tumor Study-4. Methods The mean minimum white blood cell count (WBC), platelet count (PLT), hemoglobin, and absolute neutrophil count (ANC) during the first two courses of chemotherapy and the mean number of days of hospitalization for toxicity were compared between standard and "pulse-intensive" regimens for all randomized patients entered on National Wilms' Tumor Study-4 between August 6, 1986 and December 31, 1988. The mean dose intensity of dactinomycin, vincristine, and doxorubicin received during the first two courses and the entire course of treatment was compared between standard and "pulse-intensive" regimens. Results The mean minimum WBC, PLT, and ANC were all significantly lower during the first two courses of chemotherapy for stage I patients treated with the standard regimen, compared with the "pulse-intensive" regimen. The mean dose intensity of dactinomycin and doxorubicin was significantly higher for patients treated with the "pulse-intensive" regimens, compared with the appropriate standard regimen. Conclusions The "pulse-intensive" administration schedule for the treatment of children with Wilms' tumor permits administration of chemotherapy at a higher dose intensity without an increase in hematological toxicity. |
| Databáze: | OpenAIRE |
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