Mixed selectivity morphs population codes in prefrontal cortex
| Autor: | Roger Herikstad, Jit Hon Bong, Felipe Salvador Medina, Aishwarya Parthasarathy, Shih-Cheng Yen, Camilo Libedinsky |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Patch-Clamp Techniques genetic structures Interference theory Population Prefrontal Cortex Functional Laterality 03 medical and health sciences 0302 clinical medicine Mental Processes Saccades Animals education Prefrontal cortex Self-reference effect Neurons education.field_of_study Working memory General Neuroscience Cognitive flexibility Frontal eye fields Macaca fascicularis 030104 developmental biology Memory Short-Term Visual Fields Consumer neuroscience Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Psychomotor Performance Cognitive psychology |
| Zdroj: | Nature neuroscience. 20(12) |
| ISSN: | 1546-1726 |
| Popis: | The prefrontal cortex maintains working memory information in the presence of distracting stimuli. It has long been thought that sustained activity in individual neurons or groups of neurons was responsible for maintaining information in the form of a persistent, stable code. Here we show that, upon the presentation of a distractor, information in the lateral prefrontal cortex was reorganized into a different pattern of activity to create a morphed stable code without losing information. In contrast, the code in the frontal eye fields persisted across different delay periods but exhibited substantial instability and information loss after the presentation of a distractor. We found that neurons with mixed-selective responses were necessary and sufficient for the morphing of code and that these neurons were more abundant in the lateral prefrontal cortex than the frontal eye fields. This suggests that mixed selectivity provides populations with code-morphing capability, a property that may underlie cognitive flexibility. |
| Databáze: | OpenAIRE |
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