Study of some biochemical and genetic risk factors for atherosclerosis in systemic luus erythematosus patients
| Autor: | SS Zakarial, H El Saadany, Manal El-Batch, Timour Moustafa, Heba A Mourad |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
business.industry Monocyte Blood lipids medicine.disease Pathogenesis Menopause chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry immune system diseases Internal medicine Genotype medicine Gene polymorphism skin and connective tissue diseases Asymmetric dimethylarginine business Body mass index |
| Zdroj: | Egyptian Journal of Biochemistry and Molecular Biology; Vol 28, No 1 (2010) |
| ISSN: | 1687-1502 |
| DOI: | 10.4314/ejbmb.v28i1.54369 |
| Popis: | The aim of this study was to evaluate the relation between asymmetric dimethylarginine (ADMA ), high sensitive C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1) ( both serum levels and the genotypes of the MCP-1 A-2518G polymorphism) with the development of carotid atherosclerosis in systemic lupus erythematosus patients (SLE). Thirty non menopause SLE female patients and twenty healthy age-matched females were included. Both cases and controls were subjected to evaluation of body mass index (BMI), intimal-medial thickness (IMT), fasting blood sugar (FBS), serum lipids. Serum ADMA, hs-CRP, and MCP-1, levels were measured by ELISA. MCP-1 polymorphism was detected by PCR-RFLP. Our results showed that values for IMT, hs-CRP, ADMA and MCP-1, were significantly higher in SLE patients than in healthy control with more significant increase in SLE patients with IMT genotype. In multiple regression analysis, ADMA and MCP-1 were the strongest independent determinants of IMT in SLE patients. In conclusion assessment of high levels of ADMA, hs-CRP, MPC-1, in addition to the MCP-1 G allele may play a role in the pathogenesis of accelerated atherosclerosis in SLE patients and would be useful in identifying the risk of developing atherosclerosis. Keywords: asymmetric dimethylarginine (ADMA ), gene polymorphism, high sensitive C-reactive protein (hs-CRP), intimal media thickness (IMT), monocyte chemoattractant protein-1 (MCP-1), systemic lupus erythematosus (SLE) |
| Databáze: | OpenAIRE |
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