Immunosuppression reactivates and disseminates latent murine cytomegalovirus
| Autor: | Jordan Mc, Shanley Jd, Stevens Jg |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Time Factors
medicine.drug_class medicine.medical_treatment Congenital cytomegalovirus infection Cytomegalovirus Disease Biology Virus Replication Virus Salivary Glands Pathogenesis Mice Latent Virus Recurrence Virology medicine Animals Antilymphocyte Serum Immunosuppression Therapy Mice Inbred C3H Immunosuppression medicine.disease Cortisone Regimen Disease Models Animal Organ Specificity Immunology Carrier State Cytomegalovirus Infections Corticosteroid Spleen |
| Zdroj: | The Journal of general virology. 37(2) |
| ISSN: | 0022-1317 |
| Popis: | Summary When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with anti-lymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This system should be useful in defining the pathogenesis of generalized cytomegalic disease resulting from reactivation of latent virus in immunocompromised individuals. |
| Databáze: | OpenAIRE |
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