Drug Delivery Systems Using Surface Markers for Targeting Cancer Stem Cells
| Autor: | Erin L Oswald, Haritosh Patel, Ninweh N Jeorje, James Trevor Oswald, Daid A. Khan, Shirley Tang, Hossein Golzar |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug media_common.quotation_subject Population Cell Antineoplastic Agents Biology Metastasis 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Cancer stem cell Neoplasms Drug Discovery medicine Humans education media_common Pharmacology education.field_of_study medicine.disease Nanomedicine 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Drug delivery Neoplastic Stem Cells Cancer research Efflux |
| Zdroj: | Current Pharmaceutical Design. 26:2057-2071 |
| ISSN: | 1381-6128 |
| Popis: | The innate abilities of cancer stem cells (CSCs), such as multi-drug resistance, drug efflux, quiescence and ionizing radiation tolerance, protect them from most traditional chemotherapeutics. As a result, this small subpopulation of persistent cells leads to more aggressive and chemoresistant cancers, causing tumour relapse and metastasis. This subpopulation is differentiated from the bulk tumour population through a wide variety of surface markers expressed on the cell surface. Recent developments in nanomedicine and targeting delivery methods have given rise to new possibilities for specifically targeting these markers and preferentially eliminating CSCs. Herein, we first summarize the range of surface markers identifying CSC populations in a variety of cancers; then, we discuss recent attempts to actively target CSCs and their niches using liposomal, nanoparticle, carbon nanotube and viral formulations. |
| Databáze: | OpenAIRE |
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