Fermentable carbohydrate modulates postprandial enteroglucagon and gastrin release in rats
| Autor: | Ian T. Johnson, W. E. Lee-Finglas, J. M. Gee |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Lactitol Colon Dietary lipid Glucagon-Like Peptides Medicine (miscellaneous) Enteroglucagon Biology Eating Random Allocation chemistry.chemical_compound Sugar Alcohols Internal medicine Gastrins medicine Animals Rats Wistar Cellulose Gastrin Nutrition and Dietetics Cathartics Carbohydrate Rats Endocrinology Postprandial Gastrointestinal hormone chemistry Fermentation |
| Zdroj: | British Journal of Nutrition. 75:757-766 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1079/bjn19960179 |
| Popis: | We studied the effects of a fermentable sugar-alcohol (lactitol) on the concentrations of enteroglucagon and gastrin in the blood of rats for 7·5 h after feeding. The control and treatment groups were fed on semi-purified diets containing either non-fermentable cellulose or lactitol respectively, at 100 g/kg. Compared with the cellulose-fed group, the animals fed with lactitol had higher levels of enteroglucagon (5−10 times higher than control; P < 0·05) and lower serum gastrin (70−80% of control; P< 0.·05) for several hours after the withdrawal of feed. In contrast, varying the level of dietary lipid (maize oil) over a range of 8−120 g/kg had no effect on the release of either peptide. These results suggest that poorly absorbed fermentable dietary carbohydrate stimulates postprandial plasma enteroglucagon and inhibits serum gastrin release in the rat. The mechanism is uncertain but an endocrine response by the colon to fermentation products seems probable. |
| Databáze: | OpenAIRE |
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