Enantioselective Total Synthesis and Structure Confirmation of the Natural Dimeric Tetrahydroxanthenone Dicerandrol C

Autor:	Dhandapani Ganapathy, Soundararasu Senthilkumar, Johannes R. Reiner, Guillermo Valdomir, Lutz F. Tietze
Rok vydání:	2017
Předmět:	010405 organic chemistry Stereochemistry Xanthones Organic Chemistry Absolute configuration Enantioselective synthesis Total synthesis Stereoisomerism General Chemistry 010402 general chemistry 01 natural sciences Catalysis 3. Good health 0104 chemical sciences chemistry.chemical_compound Enantiopure drug Xanthenes Suzuki reaction chemistry Cyclization Dicerandrol C Chromane Enantiomer Dimerization Palladium
Zdroj:	Chemistry - A European Journal. 23:2299-2302
ISSN:	0947-6539
DOI:	10.1002/chem.201700020
Popis:	The first enantioselective total synthesis of natural dicerandrol C (1 c) as its enantiomer containing a dimeric tetrahydroxanthenone skeleton is described starting from the enantiopure chromane 6 which was obtained through a Wacker-type cyclization with >99 % ee. For the formation of the dimeric skeleton a palladium-catalyzed Suzuki reaction was used. The synthesis allowed the confirmation of the absolute configuration of the dicerandrols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875c80a6ae11752ebb4e6f2d91347942 https://doi.org/10.1002/chem.201700020 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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