The association between diabetes medication and weight change in a non‐surgical weight management intervention: an intervention cohort study

Autor: David S. Morrison, S. MacNaughton, Philip McLoone, Ross Shearer, Billy Sloan, N. M. Aldekhail, Hanan Khojah, Jennifer Logue
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Endocrinology
Diabetes and Metabolism
Psychological intervention
030209 endocrinology & metabolism
Type 2 diabetes
Weight Gain
Incretins
Body Mass Index
RS
Cohort Studies
03 medical and health sciences
Young Adult
0302 clinical medicine
Endocrinology
Weight loss
Internal medicine
Diabetes mellitus
Weight management
Weight Loss
Internal Medicine
medicine
Humans
Hypoglycemic Agents
030212 general & internal medicine
Obesity
Sodium-Glucose Transporter 2 Inhibitors
Aged
Retrospective Studies
Dipeptidyl-Peptidase IV Inhibitors
business.industry
Weight change
Middle Aged
medicine.disease
Confidence interval
Metformin
Obesity Management
Weight Reduction Programs
Sulfonylurea Compounds
Diabetes Mellitus
Type 2
Female
Thiazolidinediones
medicine.symptom
business
Cohort study
ISSN: 0742-3071
Popis: Aim:\ud \ud To compare weight change in a lifestyle‐based weight management programme between participants taking weight‐gaining, weight‐neutral/loss and mixed diabetes medications.\ud Methods:\ud \ud Electronic health records for individuals (≥ 18 years) with Type 2 diabetes who had been referred to a non‐surgical weight management programme between February 2008 and May 2014 were studied. Diabetes medications were classified into three categories based on their effect on body weight. In this intervention cohort study, weight change was calculated for participants attending two or more sessions.\ud Results:\ud \ud All 998 individuals who took oral diabetes medications and attended two or more sessions of weight management were included. Some 59.5% of participants were women, and participants had a mean BMI of 41.1 kg/m2 (women) and 40.2 kg/m2 (men). Of the diabetes medication combinations prescribed, 46.0% were weight‐neutral/loss, 41.3% mixed and 12.7% weight‐gaining. The mean weight change for participants on weight‐gaining and weight‐neutral/loss diabetes medications respectively was −2.5 kg [95% confidence interval (CI) −3.2 to −1.8) and −3.3 kg (95% CI −3.8 to −2.9) (P = 0.05) for those attending two or more sessions (n = 998). Compared with those prescribed weight‐neutral medications, participants prescribed weight‐gaining medication lost 0.86 kg less (95% CI 0.02 to 1.7; P = 0.045) in a model adjusted for age, sex, BMI and socio‐economic status.\ud Conclusions:\ud \ud Participants on weight‐neutral/loss diabetes medications had a greater absolute weight loss within a weight management intervention compared with those on weight‐gaining medications. Diabetes medications should be reviewed ahead of planned weight‐loss interventions to help ensure maximal effectiveness of the intervention.
Databáze: OpenAIRE
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