miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP
| Autor: | Jiangtu He, Xinyi Zhu, Yue Wang, Fenyong Sun, Qiuhui Pan, Yanting Xu, Qiuling Xie |
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| Jazyk: | angličtina |
| Předmět: |
Esophageal Neoplasms
Cell Biophysics Regulator Biochemistry DAB2IP Structural Biology In vivo Esophageal squamous cell carcinoma microRNA Genetics Biomarkers Tumor Medicine Humans In patient RNA Neoplasm Molecular Biology Cell proliferation business.industry Cell growth miR-889 Cell Biology In vitro digestive system diseases Neoplasm Proteins Gene Expression Regulation Neoplastic MicroRNAs medicine.anatomical_structure ras GTPase-Activating Proteins Cancer research Carcinoma Squamous Cell Clinicopathological features business HeLa Cells |
| Zdroj: | FEBS Letters. (10):1127-1135 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2015.03.027 |
| Popis: | MicroRNAs have been reported to play critical roles in various cancers, but there has been no study on the role of miR-889 in cancers. Here, we report that over-expression of miR-889 leads to rapid proliferation of EC109 and EC9706 cells in vitro and in vivo by inducing cells into S-phase. Using bioinformatics methods, DAB2IP was further confirmed to be a direct target of miR-889. In addition, the expression of DAB2IP, which was negatively correlated with that of miR-889, was significantly associated with clinicopathological features of ESCC patients. In conclusion, miR-889 is an important regulator in ESCC and both miR-889 and DAB2IP may serve as promising biomarkers and therapeutic targets in patients with ESCC. |
| Databáze: | OpenAIRE |
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