Transgenic female mice with high human growth hormone levels are fertile and capable of normal lactation without having been pregnant
| Autor: | Andrzej Bartke, Y S Li, T E Wagner, M. Cecim, J. S. Yun, S. Milton |
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| Rok vydání: | 1992 |
| Předmět: |
Genetically modified mouse
endocrine system medicine.medical_specialty media_common.quotation_subject Transgene Recombinant Fusion Proteins Mice Transgenic Biology Luteal phase Mice Endocrinology Pregnancy Lactation Internal medicine medicine Weaning Animals RNA Messenger Promoter Regions Genetic Ovulation media_common Mice Inbred C3H Reproduction food and beverages Mice Inbred C57BL Somatropin medicine.anatomical_structure Fertility Liver Growth Hormone Female Phosphoenolpyruvate Carboxykinase (GTP) hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Endocrinology. 131(1) |
| ISSN: | 0013-7227 |
| Popis: | Transgenic mice carrying the phosphoenolpyruvate carboxykinase promoter region-human growth hormone (PEPCK-hGH) fusion gene are characterized by accelerated growth and plasma hGH levels ranging from 100 to 700 ng/ml. Both sexes are fertile, in contrast to previous findings in metallothionein-I/hGH transgenic mice in which females are sterile, apparently due to luteal failure. Virgin transgenic PEPCK/hGH females from this line produce milk and can successfully raise foster litters to weaning. We conclude that the life-long presence of very large amounts of hGH in the circulation is compatible with ovulation, can override the effects of hGH-induced suppression of endogenous PRL release, and can support full lactation in animals that have not been primed by hormonal changes associated with pregnancy. |
| Databáze: | OpenAIRE |
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