Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla
| Autor: | Rachael Lumb, Ceilidh Marchant, Andrew Joyce, Mathew Tata, Xiangjun Xu, Christiana Ruhrberg, Natasha L. Harvey, Quenten Schwarz |
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| Přispěvatelé: | Lumb, Rachael, Tata, Mathew, Xu, Xiangjun, Joyce, Andrew, Marchant, Ceilidh, Harvey, Natasha, Ruhrberg, Christiana, Schwarz, Quenten |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine endocrine system Sympathetic Nervous System Neuropilins Chromaffin Cells Biology Mice 03 medical and health sciences Semaphorin Cell Movement chromaffin cell medicine Autonomic nervous system Animals Molecular Biology Neural crest cell Adrenal gland adrenal gland Axon guidance Chromaffin cell autonomic nervous system Neural crest Axons Neuropilin-1 Neuropilin-2 Cell biology 030104 developmental biology medicine.anatomical_structure Adrenal Medulla Neural Crest axonguidance Neuropilin Ganglia neuropilin neural crest cell Adrenal medulla Research Article Developmental Biology |
| Zdroj: | Development (Cambridge, England) |
| Popis: | The adrenal medulla is composed of neuroendocrine chromaffin cells that secrete adrenaline into the systemic circulation to maintain physiological homeostasis and enable the autonomic stress response. How chromaffin cell precursors colonise the adrenal medulla and how they become connected to central nervous system-derived preganglionic sympathetic neurons remain largely unknown. By combining lineage tracing, gene expression studies, genetic ablation and the analysis of mouse mutants, we demonstrate that preganglionic axons direct chromaffin cell precursors into the adrenal primordia. We further show that preganglionic axons and chromaffin cell precursors require class 3 semaphorin (SEMA3) signalling through neuropilins (NRP) to target the adrenal medulla. Thus, SEMA3 proteins serve as guidance cues to control formation of the adrenal neuroendocrine system by establishing appropriate connections between preganglionic neurons and adrenal chromaffin cells that regulate the autonomic stress response. Summary: A new role is revealed for semaphorin/neuropilin signalling in guiding preganglionic sympathetic axons and chromaffin cell precursors into the adrenal primordia, ensuring correct regulation of the autonomic stress response. |
| Databáze: | OpenAIRE |
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