A double-blind study of adjunctive carbamazepine versus placebo on excited states of schizophrenic and schizoaffective disorders
| Autor: | Keisuke Sarai, Shosuke Watanabe, I. Yamashita, H. Itoh, R. Takahashi, Kazutoyo Inanaga, T. Okuma, H. Hazama, Saburo Otsuki |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Adolescent medicine.medical_treatment Schizoaffective disorder Placebo Double-Blind Method Internal medicine medicine Humans Psychiatry Aged Psychiatric Status Rating Scales Clinical Trials as Topic Chemotherapy Therapeutic effect Carbamazepine Middle Aged medicine.disease Psychiatry and Mental health Anticonvulsant Psychotic Disorders Schizophrenia Drug Therapy Combination Female Schizophrenic Psychology Psychology Antipsychotic Agents medicine.drug |
| Zdroj: | Acta Psychiatrica Scandinavica. 80:250-259 |
| ISSN: | 1600-0447 0001-690X |
| Popis: | A multi-institutional double-blind study comparing the therapeutic effect of adjunctive carbamazepine and placebo with standard neuroleptic treatment was performed on 162 patients with DSM-III diagnosis of schizophrenic (n = 127) or schizoaffective disorders (n = 35) who had excited states or aggressive/violent behavior that responded unsatisfactorily to neuroleptic treatment. The patients participated in a 4-week trial of carbamazepine plus neuroleptics (n = 82) or placebo plus neuroleptics (n = 80). The sum of patients with marked and moderate improvement was modestly larger in the carbamazepine group (48 vs. 30%, P less than 0.05). There was no significant difference between the carbamazepine and placebo groups in the changes of total BPRS scores, although the carbamazepine group showed more improvement on the items suspiciousness, uncooperativeness and excitement. The results suggest that carbamazepine, when used in combination with neuroleptics, is a useful drug for the treatment of excited states of patients with schizophrenic and schizoaffective disorders. |
| Databáze: | OpenAIRE |
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