Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort
| Autor: | Milan Vucetic, Jelena Roganović, Martin Freilich, David Shafer, Ljiljana Djukic, Aleksa Markovic, Bozidar Brkovic, Marija Milić, Evgenija Markovic, Nina Petrović |
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| Rok vydání: | 2020 |
| Předmět: |
Vascular Endothelial Growth Factor A
Molar Surgical stress Analgesic Mandible medicine.disease_cause Trismus Piezo 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Edema Humans SOD General Dentistry Piezosurgery Dental alveolus Pain Postoperative business.industry Tooth Impacted 030206 dentistry VEGF Lower third molar 3. Good health Vascular endothelial growth factor MicroRNAs chemistry IL-1β 030220 oncology & carcinogenesis Anesthesia Tooth Extraction Molar Third miR-21 medicine.symptom business Oxidative stress |
| Zdroj: | Clinical Oral Investigations |
| ISSN: | 1436-3771 1432-6981 |
| Popis: | Objective To evaluate an association between bone levels of inflammation/oxidative stress mediators and postoperative discomfort after third molar conventional or piezosurgery. Material and methods Twenty-six subjects with bilaterally impacted mandibular third molars, who underwent either piezo or conventional surgery, were included in a split-mouth design study. MicroRNA-21 (miR-21) expression, interleukin-1 beta (IL1β), and vascular endothelial growth factor (VEGF) proteins, as well as superoxide dismutase (SOD) activity in alveolar bone, were evaluated. Pain intensity, the first pain appearance, analgesic first use and total dose taken, trismus, and swelling were clinically recorded. Results MiR-21 expression was higher while VEGF protein was lower in piezosurgery vs. conventional groups. The differences in IL-1β protein and SOD activity were not significant between groups. The pain intensity on the first day was significantly decreased in piezosurgery group. The first pain appearance and the first analgesic taken were reported sooner in conventional vs. piezosurgical group. Significantly pronounced trismus on the third day following conventional surgery was found. In conventional group, significantly increased trismus was observed on the third compared to the first postoperative day. MiR-21 showed significant correlation with the first pain appearance. Conclusion Delayed onset of less pronounced postoperative pain after piezosurgical vs. conventional extraction of impacted lower third molar was significantly associated with expression of bone miR-21. Clinical relevance Alveolar bone miR-21 may reflect surgical stress and is associated with third molar postoperative pain onset. |
| Databáze: | OpenAIRE |
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