H pylori eradication: A randomized prospective study of triple therapy with or without ecabet sodium
| Autor: | Gwang Ha Kim, Chul Soo Song, Hyung Wook Kim, Ung Suk Yang, Geun Am Song, Seung Keun Park, Jong Yun Cheong, Dae Hwan Kang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Ecabet sodium medicine.medical_specialty macromolecular substances Gastroenterology Group A Group B Helicobacter Infections Anti-Infective Agents Internal medicine medicine Humans Prospective Studies Prospective cohort study Aged Breath test medicine.diagnostic_test Helicobacter pylori business.industry General Medicine Middle Aged H pylori infection Anti-Ulcer Agents Surgery Treatment Outcome Breath Tests Abietanes Drug Therapy Combination Female business Rapid Communication |
| Popis: | AIM: To investigate whether adding ecabet sodium to the standard triple therapy for H pylori infection improve eradication rate. METHODS: Two hundred and fifty-seven H pylori-infected patients were randomly assigned to standard triple therapy (group A, n = 129) or triple therapy plus ecabet sodium (group B, n = 128). Successful eradication was defined as a negative 13C-urea breath test 6-8 wk after completion of treatment. RESULTS: After completion of therapy, 194/257 patients showed negative 13C-urea breath test results. According to intention-to-treat analysis, the infection was eradicated in 93/129 (72.1%) patients in group A and 101/128 (78.9%) in group B (P = 0.204). Per-protocol analysis showed successful eradication in 93/118 (78.8%) patients from group A and 101/114 (88.6%) from group B (P = 0.044). There were no significant differences in the side effects experienced by the patients in the two treatment groups. CONCLUSION: Our results suggest that the addition of ecabet sodium improves the efficacy of the standard triple therapy for H pylori. |
| Databáze: | OpenAIRE |
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