Forearm vasodilator mechanisms during mental stress: possible roles for epinephrine and ANP
| Autor: | Madeleine Lindqvist, Paul Hjemdahl, Anders Melcher, P. Bie, Thomas Kahan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Vasopressin Epinephrine Physiology Endocrinology Diabetes and Metabolism Hemodynamics Blood Pressure Vasodilation Atrial natriuretic peptide Forearm Heart Rate Physiology (medical) Internal medicine parasitic diseases medicine Humans Infusions Intra-Arterial Infusions Intravenous Analysis of Variance Dose-Response Relationship Drug business.industry Videotape Recording Middle Aged medicine.anatomical_structure Blood pressure Endocrinology Regional Blood Flow Vascular resistance Vascular Resistance business Atrial Natriuretic Factor Stress Psychological medicine.drug |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 270:E393-E399 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1996.270.3.e393 |
| Popis: | The contribution of epinephrine (Epi) to forearm vasodilator responses to mental stress was evaluated in 12 healthy men by comparing hemodynamic and plasma catecholamine responses to mental stress and to intravenous and intra-arterial infusions of epinephrine. Mental stress decreased forearm vascular resistance (FVR) by 45%, increased arterial Epi from 0.23 to 0.44 nmol/l in arterial plasma, and increased forearm norepinephrine overflow. Intra-arterial Epi infusion decreased FVR concentration dependently by up to 43%. Intravenous Epi infusion decreased diastolic arterial pressure and increased heart rate and systolic blood pressure dose dependently. FVR decreased by up to 39% at 4.60 nmol/l Epi in arterial plasma. The average Epi contribution to forearm vasodilation during mental stress was calculated to be between 9 and 30%, depending on if responses to stress were compared with intravenous or intra-arterial Epi infusion. Arterial atrial natriuretic peptide immunoreactivity increased by 23% during stress, supporting a vasodilator influence, whereas vasopressin immunoreactivity was unaffected. Thus secretion of Epi explains only part of the stress-induced forearm vasodilation. Intravenous infusion of Epi appears to activate sympathetic counterregulation. |
| Databáze: | OpenAIRE |
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