Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes
| Autor: | Mahlet G. Tadesse, Edward J. Boyko, Karin Hevner, Daniel A. Enquobahrie, Tanya K. Sorensen, Pandora L. Wander, Michelle A. Williams, Viraj J. Parikh |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Risk 0301 basic medicine medicine.medical_specialty Offspring Endocrinology Diabetes and Metabolism Type 2 diabetes Overweight Article 03 medical and health sciences Endocrinology Pregnancy Internal Medicine Humans Medicine Obesity Prospective cohort study Gynecology business.industry Obstetrics nutritional and metabolic diseases Gestational age General Medicine medicine.disease Pregnancy Complications Gestational diabetes Diabetes Gestational MicroRNAs 030104 developmental biology Diabetes Mellitus Type 2 Gestation Female medicine.symptom business |
| Zdroj: | Diabetes Research and Clinical Practice. 132:1-9 |
| ISSN: | 0168-8227 |
| Popis: | Aims Epigenetic regulators, including microRNAs (miRNAs), are implicated in type 2 diabetes, but evidence linking circulating miRNAs in pregnancy and risk of gestational diabetes (GDM) is sparse. Potential modifiers, including pre-pregnancy overweight/obesity and offspring sex, are unexamined. We hypothesized that circulating levels of early–mid-pregnancy (range 7–23 weeks of gestation) candidate miRNAs are related to subsequent development of GDM. We also hypothesized that miRNA-GDM associations might vary by pre-pregnancy body-mass index (ppBMI) or offspring sex. Methods In a case-control analysis (36 GDM cases/80 controls) from the Omega study, a prospective cohort study of pregnancy complications, we measured early–mid-pregnancy plasma levels of 10 miRNAs chosen for potential roles in pregnancy course and complications (miR-126-3p, -155-5p, -21-3p, -146b-5p, -210-3p, -222-3p, -223-3p, -517-5p, -518a-3p, and 29a-3p) using qRT-PCR. Logistic regression models adjusted for gestational age at blood draw (GA) were fit to compare circulating miRNAs between cases and controls. We repeated analyses among overweight/obese (ppBMI ≥ 25 kg/m 2 ) or lean (ppBMI 2 ) women, and women with male or female offspring separately. Results Mean age was 34.3 years (cases) and 32.9 years (controls). GA-adjusted miR-155-5p (β = 0.260/p = 0.028) and -21-3p (β = 0.316/p = 0.005) levels were positively associated with GDM. MiR-146b-5p (β = 0.266/p = 0.068) and miR-517-5p (β = 0.196/p = 0.074) were borderline. Associations of miR-21-3p and miR-210-3p with GDM were observed among overweight/obese but not lean women. Associations of six miRNAs (miR-155-5p, -21-3p, -146b-5p, -223-3p, -517-5p, and -29a-3p) with GDM were present only among women carrying male fetuses (all p Conclusions Circulating early–mid-pregnancy miRNAs are associated with GDM, particularly among women who are overweight/obese pre-pregnancy or pregnant with male offspring. This area has potential to clarify mechanisms underlying GDM pathogenesis and identify at-risk mothers earlier in pregnancy. |
| Databáze: | OpenAIRE |
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