Controlled Release of Matrix Metalloproteinase 1 with or without Skeletal Myoblasts Transplantation Improves Cardiac Function of Rat Hearts with Chronic Myocardial Infarction
| Autor: | Michael Fu, Akira Marui, Masaya Yamamoto, Yutaka Sakakibara, Yasuhiko Tabata, Goditha U. Premaratne, Xue Lin, Tadashi Ikeda, Keiichi Tammbara, Masashi Komeda |
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| Rok vydání: | 2009 |
| Předmět: |
Cardiac function curve
Cardiac Catheterization medicine.medical_specialty Myoblasts Skeletal Myocardial Infarction Biomedical Engineering Fluorescent Antibody Technique Infarction Bioengineering Biochemistry Biomaterials Fibrosis Internal medicine medicine Animals Humans Myocyte Ultrasonography Cardioprotection Ischemic cardiomyopathy business.industry Myocardium DNA Organ Size medicine.disease Tissue Donors Rats Transplantation Rats Inbred Lew Delayed-Action Preparations Heart failure Chronic Disease Heart Function Tests cardiovascular system Cardiology Matrix Metalloproteinase 1 business Plasmids |
| Zdroj: | Tissue Engineering Part A. 15:2699-2706 |
| ISSN: | 1937-335X 1937-3341 |
| DOI: | 10.1089/ten.tea.2008.0637 |
| Popis: | Skeletal myoblast transplantation has been applied clinically for severe ischemic cardiomyopathy. Matrix metalloproteinase 1 (MMP-1) reduces fibrosis and prevents the progress of heart failure. We hypothesized that MMP-1 administration to the infarct area enhances the efficacy of skeletal myoblast transplantation. The controlled release of MMP-1 improved cardiac functions of rats with chronic myocardiac infarction with or without transplantation of skeletal myoblasts. Improvement in cardiac function and small fibrotic area inside the infarcted area were observed compared with those of myoblast transplantation. In conclusion, controlled release of MMP-1 was effective in cardioprotection in postmyocardial infarction although the combination with cell transplantation showed the similar effect. |
| Databáze: | OpenAIRE |
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