Inhibition of C5a des Arg-induced neutrophil alveolitis in transgenic mice expressing C-reactive protein
| Autor: | Dongyuan Xia, D. Samols, Robert O. Webster, Rita M. Heuertz |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
Physiology Neutrophils Vascular permeability Inflammation Mice Transgenic Lung injury Mice Physiology (medical) medicine Animals Anaphylatoxin biology medicine.diagnostic_test Complement C5a des-Arginine C-reactive protein Acute-phase protein Cell Biology Pneumonia respiratory system medicine.disease Diet Rats Pulmonary Alveoli Chemotaxis Leukocyte Bronchoalveolar lavage C-Reactive Protein Immunology biology.protein Rabbits medicine.symptom Infiltration (medical) Bronchoalveolar Lavage Fluid |
| Zdroj: | The American journal of physiology. 266(6 Pt 1) |
| ISSN: | 0002-9513 |
| Popis: | C-reactive protein (CRP) is the classic acute phase reactant in man with serum levels elevated up to 1,000-fold after the onset of inflammation. CRP inhibits chemotaxis of complement (C5a)-stimulated neutrophils in vitro and rabbits with elevated serum CRP levels exhibit diminished neutrophil infiltration and vascular permeability in a model of C5a-induced alveolitis. To specifically evaluate the effect of CRP on C5a-induced neutrophil inflammation in vivo, experiments were performed in transgenic mice capable of expressing rabbit CRP in an inducible fashion. After direct instillation of a known inflammatory agent (C5a des Arg) into the airways, transgenic mice with high plasma levels of CRP showed significantly diminished infiltration of neutrophils into bronchoalveolar lavage fluid (BALF) and a significant reduction of BALF total protein levels compared with normal mice. These data indicate that CRP can diminish lung injury by a reduction in neutrophil influx and protein leakage into alveoli following complement-induced inflammation. |
| Databáze: | OpenAIRE |
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