Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus
Autor: | Beate M. Kümmerer, Kerstin I. Falk, Eduardo Samo Gudo, Onélia Guiliche, Argentina Felisbela Muianga, Igor A.D. Paploski, Uriel Kitron, Mitermayer G. Reis, Virgilio Santo Antonio, Vanessa Monteiro, Imelda Chelene, John Oludele, Flora Mula, Vánio André Mugabe, Guilherme S. Ribeiro, Sadia Ali, Inocencio Salvador Chongo |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male RNA viruses Viral Diseases Physiology lcsh:Medicine Dengue virus Disease Vectors medicine.disease_cause Pathology and Laboratory Medicine Mosquitoes Biochemistry Dengue fever Disease Outbreaks Dengue Geographical Locations 0302 clinical medicine Immune Physiology Medicine and Health Sciences Chikungunya Enzyme-Linked Immunoassays lcsh:Science Mozambique Rapid diagnostic test education.field_of_study Multidisciplinary Chikungunya Virus Immune System Proteins biology Eukaryota virus diseases 3. Good health Insects Infectious Diseases Medical Microbiology Viral Pathogens Viruses Female Pathogens Research Article Neglected Tropical Diseases Adult medicine.medical_specialty Adolescent Arthropoda Alphaviruses 030231 tropical medicine Population Immunology Aedes aegypti Aedes Aegypti Research and Analysis Methods Microbiology Antibodies Togaviruses 03 medical and health sciences Young Adult Internal medicine medicine Parasitic Diseases Humans Animals education Immunoassays Microbial Pathogens Biology and life sciences business.industry lcsh:R Organisms Outbreak Chikungunya Infection Proteins medicine.disease biology.organism_classification Tropical Diseases Invertebrates Insect Vectors Malaria Species Interactions 030104 developmental biology People and Places Africa Immunologic Techniques Chikungunya Fever lcsh:Q business |
Zdroj: | PLoS ONE, Vol 13, Iss 2, p e0192110 (2018) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Background In January 2016, health authorities from Zambezia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study to investigate a potential chikungunya outbreak in the city of Quelimane. Methods/Principal findings From February to June 2016, we conducted a cross-sectional study enrolling febrile patients attending five outpatient health units in Quelimane. Serum from each patient was tested for CHIKV and DENV, using IgM and IgG ELISA and qRT-PCR. Patients were also tested for malaria by RDT. Entomological surveys were performed around patients’ households, and we calculated the proportion of positive ovitraps and the egg density per trap. A total of 163 patients were recruited, of which 99 (60.7%) were female. The median age was 28 years. IgM and IgG anti-CHIKV antibodies were identified in 17 (10.4%) and 103 (63.2%) patients, respectively. Plaque reduction neutralization assay confirmed the presence of anti-CHIKV antibodies in a subset of 11 tested patients with positive IgG results. IgM anti-DENV antibodies were found in 1 (0.9%) of 104 tested patients. Malaria was diagnosed in 35 (21.5%) patients, 2 of whom were also IgM-positive for CHIKV. Older age and lower education level were independently associated with the prevalence of IgG anti-CHIKV antibodies. Immature forms of Aedes aegypti were collected in 16 (20.3%) of 79 surveyed households. We also found that 25.0% (16/64) of the traps were positive, with an average of 90.8 eggs per pallet. Conclusions Our investigation demonstrated that no CHIKV outbreak was ongoing in Quelimane; rather, endemic transmission of the virus has been ongoing. Aedes aegypti mosquitoes are abundant, but dengue cases occurred only sporadically. Further population-based cohort studies are needed to improve our understanding of aspects related to the dynamics of arboviral transmission in Mozambique, as well as in other parts of Sub-Saharan Africa. |
Databáze: | OpenAIRE |
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