Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus

Autor: Beate M. Kümmerer, Kerstin I. Falk, Eduardo Samo Gudo, Onélia Guiliche, Argentina Felisbela Muianga, Igor A.D. Paploski, Uriel Kitron, Mitermayer G. Reis, Virgilio Santo Antonio, Vanessa Monteiro, Imelda Chelene, John Oludele, Flora Mula, Vánio André Mugabe, Guilherme S. Ribeiro, Sadia Ali, Inocencio Salvador Chongo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
RNA viruses
Viral Diseases
Physiology
lcsh:Medicine
Dengue virus
Disease Vectors
medicine.disease_cause
Pathology and Laboratory Medicine
Mosquitoes
Biochemistry
Dengue fever
Disease Outbreaks
Dengue
Geographical Locations
0302 clinical medicine
Immune Physiology
Medicine and Health Sciences
Chikungunya
Enzyme-Linked Immunoassays
lcsh:Science
Mozambique
Rapid diagnostic test
education.field_of_study
Multidisciplinary
Chikungunya Virus
Immune System Proteins
biology
Eukaryota
virus diseases
3. Good health
Insects
Infectious Diseases
Medical Microbiology
Viral Pathogens
Viruses
Female
Pathogens
Research Article
Neglected Tropical Diseases
Adult
medicine.medical_specialty
Adolescent
Arthropoda
Alphaviruses
030231 tropical medicine
Population
Immunology
Aedes aegypti
Aedes Aegypti
Research and Analysis Methods
Microbiology
Antibodies
Togaviruses
03 medical and health sciences
Young Adult
Internal medicine
medicine
Parasitic Diseases
Humans
Animals
education
Immunoassays
Microbial Pathogens
Biology and life sciences
business.industry
lcsh:R
Organisms
Outbreak
Chikungunya Infection
Proteins
medicine.disease
biology.organism_classification
Tropical Diseases
Invertebrates
Insect Vectors
Malaria
Species Interactions
030104 developmental biology
People and Places
Africa
Immunologic Techniques
Chikungunya Fever
lcsh:Q
business
Zdroj: PLoS ONE, Vol 13, Iss 2, p e0192110 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Background In January 2016, health authorities from Zambezia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study to investigate a potential chikungunya outbreak in the city of Quelimane. Methods/Principal findings From February to June 2016, we conducted a cross-sectional study enrolling febrile patients attending five outpatient health units in Quelimane. Serum from each patient was tested for CHIKV and DENV, using IgM and IgG ELISA and qRT-PCR. Patients were also tested for malaria by RDT. Entomological surveys were performed around patients’ households, and we calculated the proportion of positive ovitraps and the egg density per trap. A total of 163 patients were recruited, of which 99 (60.7%) were female. The median age was 28 years. IgM and IgG anti-CHIKV antibodies were identified in 17 (10.4%) and 103 (63.2%) patients, respectively. Plaque reduction neutralization assay confirmed the presence of anti-CHIKV antibodies in a subset of 11 tested patients with positive IgG results. IgM anti-DENV antibodies were found in 1 (0.9%) of 104 tested patients. Malaria was diagnosed in 35 (21.5%) patients, 2 of whom were also IgM-positive for CHIKV. Older age and lower education level were independently associated with the prevalence of IgG anti-CHIKV antibodies. Immature forms of Aedes aegypti were collected in 16 (20.3%) of 79 surveyed households. We also found that 25.0% (16/64) of the traps were positive, with an average of 90.8 eggs per pallet. Conclusions Our investigation demonstrated that no CHIKV outbreak was ongoing in Quelimane; rather, endemic transmission of the virus has been ongoing. Aedes aegypti mosquitoes are abundant, but dengue cases occurred only sporadically. Further population-based cohort studies are needed to improve our understanding of aspects related to the dynamics of arboviral transmission in Mozambique, as well as in other parts of Sub-Saharan Africa.
Databáze: OpenAIRE
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